HAS2 - Hyaluronan synthase 2 - human protein (Function)
 
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HAS2 »  Hyaluronan synthase 2   [ EC 2.4.1.212 ]
 
Protein also known as:  Hyaluronic acid synthase 2 (HA synthase 2).
Gene name:  HAS2
Family name: NodC/HAS
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. May also play a role in vasculogenesis. High molecular mass hyaluronan also play a role in early contact inhibition a process which stops cell growth when cells come into contact with each other or the extracellular matrix (By similarity).  
1
  • UniProtKB
GO molecular function 
Hyaluronan synthase activitydefinition[GO:0050501]  
2
  • BHF-UCL
  • Ortholog Curator
GO biological process 
Atrioventricular canal developmentdefinition[GO:0036302]  
1
  • Ortholog Curator
Bone morphogenesisdefinition[GO:0060349] silver  
1
  • Ortholog Compara
Cellular response to fluid shear stressdefinition[GO:0071498]  
1
  • BHF-UCL
Cellular response to interleukin-1definition[GO:0071347]  
1
  • BHF-UCL
Cellular response to platelet-derived growth factor stimulusdefinition[GO:0036120]  
1
  • UniProtKB
Cellular response to tumor necrosis factordefinition[GO:0071356]  
1
  • BHF-UCL
Endocardial cushion to mesenchymal transitiondefinition[GO:0090500]  
1
  • Ortholog Curator
Extracellular matrix assemblydefinition[GO:0085029]  
2
  • RefGenome
  • Ortholog Curator
Extracellular polysaccharide biosynthetic processdefinition[GO:0045226]  
2
  • RefGenome
  • Ortholog Curator
Hyaluronan biosynthetic processdefinition[GO:0030213]  
4
  • BHF-UCL
  • UniProtKB
  • UniPathway
  • Ortholog Curator
Kidney developmentdefinition[GO:0001822]  
1
  • Ortholog Curator
Positive regulation of cell migrationdefinition[GO:0030335]  
1
  • BHF-UCL
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • BHF-UCL
Positive regulation of monocyte aggregationdefinition[GO:1900625]  
1
  • BHF-UCL
Positive regulation of urine volumedefinition[GO:0035810]  
1
  • Ortholog Curator
Renal water absorptiondefinition[GO:0070295]  
1
  • Ortholog Curator
Vasculogenesisdefinition[GO:0001570]  
1
  • Ortholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan) UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan).  
1
  • UniProtKB
UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan) UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan).  
1
  • UniProtKB
It requires the following cofactor
 Mg(2+)  
1
  • UniProtKB
According to CAZy, this protein is belongs to the following pathway:
Glycosyltransferase Family 2  GT2  
 
More information is available from:
Pathways 
This protein is involved in the following pathway
Glycan biosynthesis; hyaluronan biosynthesis  
1
  • UniProtKB
According to Reactome, this protein belongs to the following pathway:
Hyaluronan biosynthesis and export  REACT_121301  
 

Keywords

Molecular function 
Glycosyltransferase  definition   [KW-0328]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: HAS2
GenomeRNAi: 3037
PRO: PR:Q92819