HAS2 - Hyaluronan synthase 2 - human protein (Function)
 
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HAS2 »  Hyaluronan synthase 2   [ EC 2.4.1.212 ]
 
Protein also known as:  Hyaluronic acid synthase 2 (HA synthase 2).
Gene name:  HAS2
Family name: NodC/HAS
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. May also play a role in vasculogenesis. High molecular mass hyaluronan also play a role in early contact inhibition a process which stops cell growth when cells come into contact with each other or the extracellular matrix (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Hyaluronan synthase activitydefinition[GO:0050501]  
1
  • IMPBHF-UCL
  • ISSOrtholog Curator
GO biological process 
Atrioventricular canal developmentdefinition[GO:0036302]  
  • ISSOrtholog Curator
Bone morphogenesisdefinition[GO:0060349] silver  
  • IEAOrtholog Compara
Cellular response to fluid shear stressdefinition[GO:0071498]  
1
  • IEPBHF-UCL
Cellular response to interleukin-1definition[GO:0071347]  
1
  • IEPBHF-UCL
Cellular response to platelet-derived growth factor stimulusdefinition[GO:0036120]  
1
  • IDAUniProtKB
Cellular response to tumor necrosis factordefinition[GO:0071356]  
1
  • IEPBHF-UCL
Endocardial cushion to mesenchymal transitiondefinition[GO:0090500]  
  • ISSOrtholog Curator
Extracellular matrix assemblydefinition[GO:0085029]  
  • ISSOrtholog Curator
Extracellular polysaccharide biosynthetic processdefinition[GO:0045226]  
  • ISSOrtholog Curator
Hyaluronan biosynthetic processdefinition[GO:0030213]  
2
  • IMPBHF-UCL
  • IDAUniProtKB
  • IEAUniPathway
  • ISSOrtholog Curator
Kidney developmentdefinition[GO:0001822]  
  • ISSOrtholog Curator
Positive regulation of cell migrationdefinition[GO:0030335]  
1
  • IMPBHF-UCL
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • IMPBHF-UCL
Positive regulation of monocyte aggregationdefinition[GO:1900625]  
1
  • IMPBHF-UCL
Positive regulation of urine volumedefinition[GO:0035810]  
  • ISSOrtholog Curator
Renal water absorptiondefinition[GO:0070295]  
  • ISSOrtholog Curator
Vasculogenesisdefinition[GO:0001570]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan) UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan).  
  • CuratedUniProtKB
UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan) UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan).  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium.  
  • CuratedUniProtKB
According to CAZy, this protein is belongs to the following pathway:
Glycosyltransferase Family 2  GT2  
 
More information is available from:
Pathways 
This protein is involved in the following pathway
According to Reactome, this protein belongs to the following pathway:
Hyaluronan biosynthesis and export  REACT_121301  
 

Keywords

Molecular function 
Glycosyltransferase  definition   [KW-0328]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: HAS2
GenomeRNAi: 3037
PRO: PR:Q92819