GGH - Gamma-glutamyl hydrolase - human protein (Function)
 
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Protein
Gene
References

 
GGH »  Gamma-glutamyl hydrolase   [ EC 3.4.19.9 ]
 
Protein also known as:  Gamma-Glu-X carboxypeptidase.
Gene name:  GGH
Family name: Peptidase C26
Entry whose protein(s) existence is based on evidence at protein level
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1 39 1
GENE REF ISO

Function

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Overview 
Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates.  
  • CuratedUniProtKB
GO molecular function 
Exopeptidase activitydefinition[GO:0008238]  
1
  • TASPINC
Gamma-glutamyl-peptidase activitydefinition[GO:0034722]  
1
  • IDAUniProtKB
Omega peptidase activitydefinition[GO:0008242]  
1
  • TASPINC
GO biological process 
Glutamine metabolic processdefinition[GO:0006541] silver  
  • IEAInterPro 2 GO
Proteolysisdefinition[GO:0006508]  
2
  • IDAGOC
  • IEAEC 2 GO
  • IEAInterPro 2 GO
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to ethanoldefinition[GO:0045471] silver  
  • IEAOrtholog Compara
Response to insulindefinition[GO:0032868] silver  
  • IEAOrtholog Compara
Response to zinc iondefinition[GO:0010043] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.19.9: Hydrolysis of a gamma-glutamyl bond.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Folate biosynthesis  hsa00790+8836  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GGH_(gene)
GenomeRNAi: 8836
PRO: PR:Q92820