RPGR - X-linked retinitis pigmentosa GTPase regulator - human protein (Function)
 
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Protein
Gene
References

 
RPGR »  X-linked retinitis pigmentosa GTPase regulator
 
Gene name:  RPGR
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Could be a guanine-nucleotide releasing factor. Plays a role in ciliogenesis. Probably regulates cilia formation by regulating actin stress filaments and cell contractility. Plays an important role in photoreceptor integrity. May play a critical role in spermatogenesis and in intraflagellar transport processes (By similarity). May be involved in microtubule organization and regulation of transport in primary cilia.  
1
  • CuratedUniProtKB
GO molecular function 
Guanyl-nucleotide exchange factor activitydefinition[GO:0005085]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
  • IPIUniProtKB
GO biological process 
Cilium assemblydefinition[GO:0042384]  
1
  • IMPUniProtKB
Eye photoreceptor cell developmentdefinition[GO:0042462] silver  
  • IEAOrtholog Compara
Intracellular protein transportdefinition[GO:0006886]  
1
  • TASPINC
Intraciliary transportdefinition[GO:0042073]  
  • ISSOrtholog Curator
Response to stimulusdefinition[GO:0050896]  
  • IEAUniProtKB KW
Visual perceptiondefinition[GO:0007601]  
1
  • IMPUniProtKB
 

Keywords

Biological process 
Cilium biogenesis/degradation  definition   [KW-0970]
Sensory transduction  definition   [KW-0716]
Vision  definition   [KW-0844]
Molecular function 
Guanine-nucleotide releasing factor  definition   [KW-0344]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links