HAS1 - Hyaluronan synthase 1 - human protein (Function)
 
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HAS1 »  Hyaluronan synthase 1   [ EC 2.4.1.212 ]
 
Protein also known as:  Hyaluronic acid synthase 1 (HuHAS1).
Gene name:  HAS1
Family name: NodC/HAS
Entry whose protein(s) existence is based on evidence at protein level
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1 46 1
GENE REF ISO

Function

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Overview 
Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate (By similarity).  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the putative vectorial glycosyl polymerization (vgp) family  4.D.1.2.1  
GO molecular function 
Hyaluronan synthase activitydefinition[GO:0050501]  
  • ISSOrtholog Curator
GO biological process 
Cell adhesiondefinition[GO:0007155]  
1
  • TASPINC
Cellular response to platelet-derived growth factor stimulusdefinition[GO:0036120]  
1
  • IDAUniProtKB
Extracellular matrix assemblydefinition[GO:0085029]  
  • ISSOrtholog Curator
Extracellular polysaccharide biosynthetic processdefinition[GO:0045226]  
  • ISSOrtholog Curator
Glycosaminoglycan biosynthetic processdefinition[GO:0006024]  
1
  • TASPINC
Hyaluronan biosynthetic processdefinition[GO:0030213]  
  • IEAUniPathway
Negative regulation of fibroblast migrationdefinition[GO:0010764]  
1
  • IMPUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan) UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan).  
  • CuratedUniProtKB
UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan) UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan).  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium.  
  • CuratedUniProtKB
According to CAZy, this protein is belongs to the following pathway:
Glycosyltransferase Family 2  GT2  
 
More information is available from:
Pathways 
This protein is involved in the following pathway
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Metabolism  REACT_111217  
 

Keywords

Molecular function 
Glycosyltransferase  definition   [KW-0328]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: HAS1
GenomeRNAi: 3036
PRO: PR:Q92839