BCL2L2 - Bcl-2-like protein 2 - human protein (Function)
 
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BCL2L2 »  Bcl-2-like protein 2  (Bcl2-L-2)
 
Protein also known as:  Apoptosis regulator Bcl-W.
Gene name:  BCL2L2
Family name: Bcl-2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 53 2
GENE REF ISO

Function

 show evidences
Overview 
Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the bcl-2 (bcl-2) family  1.A.21.1.5  
GO molecular function 
BH domain bindingdefinition[GO:0051400] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
6
  • IPIIntAct
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IBARefGenome
Protein homodimerization activitydefinition[GO:0042803] silver  
  • IBARefGenome
GO biological process 
Extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:0097192] silver  
  • IBARefGenome
Intrinsic apoptotic signaling pathway in response to DNA damagedefinition[GO:0008630] silver  
  • IBARefGenome
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • IMPUniProtKB
Negative regulation of intrinsic apoptotic signaling pathwaydefinition[GO:2001243] silver  
  • IBARefGenome
Sertoli cell proliferationdefinition[GO:0060011] silver  
  • IEAOrtholog Compara
Spermatogenesisdefinition[GO:0007283]  
1
  • TASPINC
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: BCL2L2
GenomeRNAi: 599
PRO: PR:Q92843