TANK - TRAF family member-associated NF-kappa-B activator - human protein (Function)
 
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Protein
Gene
References

 
TANK »  TRAF family member-associated NF-kappa-B activator
 
Protein also known as:  TRAF-interacting protein (I-TRAF).
Gene name:  TANK
Entry whose protein(s) existence is based on evidence at protein level
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1 46 3
GENE REF ISO

Function

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Overview 
Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2.  
2
  • CuratedUniProtKB
GO molecular function 
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
11
  • IPIIntAct
  • IPIUniProtKB
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • IPIUniProtKB
GO biological process 
I-kappaB kinase/NF-kappaB signalingdefinition[GO:0007249] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathway:
RIG-I-like receptor signaling pathway  hsa04622+10010  
According to Reactome, this protein belongs to the following pathway:
TRAF6 mediated IRF7 activation  REACT_24938  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TANK_(gene)
GenomeRNAi: 10010
PRO: PR:Q92844