CASP10 - Caspase-10 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
CASP10 »  Caspase-10   [ EC 3.4.22.63 ]  (CASP-10)
 
Protein also known as:  FAS-associated death domain protein interleukin-1B-converting enzyme 2 (FLICE2). Cleaved into:  Caspase-10 subunit p12; Caspase-10 subunit p23/17.
Gene name:  CASP10
Family name: Peptidase C14A
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 76 7
GENE REF ISO

Function

 show evidences
Overview 
Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC.  
1
  • CuratedUniProtKB
Isoform  C   Is proteolytically inactive.  
1
  • CuratedUniProtKB
GO molecular function 
Cysteine-type endopeptidase activitydefinition[GO:0004197] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
6
  • IPIIntAct
  • IPIUniProtKB
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • IPIUniProtKB
GO biological process 
Positive regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043123]  
2
  • RCAUniProtKB
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Regulation of apoptotic processdefinition[GO:0042981] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.22.63: Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Leu-Gln-Thr-Asp-|-Gly.  
  • CuratedUniProtKB
It is regulated in the following manner
Negatively regulated by RFFL through proteasomal degradation.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Apoptosis  hsa04210+843  
RIG-I-like receptor signaling pathway  hsa04622+843  
Tuberculosis  hsa05152+843  
According to Reactome, this protein belongs to the following pathways:
Apoptosis  REACT_578  
Immune System  REACT_6900  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Caspase_10
GenomeRNAi: 843
PRO: PR:Q92851