ATOH1 - Protein atonal homolog 1 - human protein (Function)
 
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ATOH1 »  Protein atonal homolog 1
 
Protein also known as:  Class A basic helix-loop-helix protein 14 (bHLHa14).
Gene name:  ATOH1
Entry whose protein(s) existence is based on evidence at transcript level
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1 34 1
GENE REF ISO

Function

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Overview 
Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity).  
1
  • UniProtKB
GO molecular function 
Chromatin DNA bindingdefinition[GO:0031490] silver  
1
  • Ortholog Compara
Protein dimerization activitydefinition[GO:0046983] silver  
1
  • InterPro 2 GO
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978] silver  
1
  • Ortholog Compara
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077] silver  
1
  • Ortholog Compara
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • PINC
GO biological process 
Auditory receptor cell fate determinationdefinition[GO:0042668] silver  
1
  • Ortholog Compara
Auditory receptor cell fate specificationdefinition[GO:0042667] silver  
1
  • Ortholog Compara
Axon guidancedefinition[GO:0007411] silver  
1
  • Ortholog Compara
Central nervous system developmentdefinition[GO:0007417]  
1
  • PINC
Cerebral cortex developmentdefinition[GO:0021987] silver  
1
  • Ortholog Compara
Inner ear morphogenesisdefinition[GO:0042472] silver  
1
  • Ortholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
1
  • Ortholog Compara
Neuron migrationdefinition[GO:0001764] silver  
1
  • Ortholog Compara
Positive regulation of auditory receptor cell differentiationdefinition[GO:0045609] silver  
1
  • Ortholog Compara
Positive regulation of neuron differentiationdefinition[GO:0045666]  
1
  • Ortholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
1
  • Ortholog Compara
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • PINC
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Neurogenesis  definition   [KW-0524]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ATOH1
GenomeRNAi: 474
PRO: PR:Q92858