PMM1 - Phosphomannomutase 1 - human protein (Function)
 
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Gene
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PMM1 »  Phosphomannomutase 1   [ EC 5.4.2.8 ]  (PMM 1)
 
Protein also known as:  PMMH-22.
Gene name:  PMM1
Family name: Eukaryotic PMM
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain.  
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  • UniProtKB
GO molecular function 
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Phosphomannomutase activitydefinition[GO:0004615]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
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  • IntAct
GO biological process 
GDP-mannose biosynthetic processdefinition[GO:0009298]  
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  • UniPathway
Mannose biosynthetic processdefinition[GO:0019307] silver  
1
  • InterPro 2 GO
Mannose metabolic processdefinition[GO:0006013]  
1
  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5.4.2.8: Alpha-D-mannose 1-phosphate D-mannose 6-phosphate.  
1
  • UniProtKB
It requires the following cofactor
 Mg(2+)  
2
  • UniProtKB
It is regulated in the following manner
IMP, a metabolite whose concentration is elevated in anoxia, inhibits phosphomannomutase and phosphoglucomutase activities and strongly enhances glucose-1,6-bisphosphatase activity.  
1
  • UniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
1
  • UniProtKB
According to KEGG, this protein belongs to the following pathways:
Amino sugar and nucleotide sugar metabolism  hsa00520+5372  
Fructose and mannose metabolism  hsa00051+5372  
Metabolic pathways  hsa01100+5372  
According to Reactome, this protein belongs to the following pathway:
Synthesis of GDP-mannose  REACT_22423  
 

Biophysicochemical properties

Kinetic parameters
KM 54 uM for alpha-D-mannose 1-phosphate
KM 7.5 uM for alpha-D-glucose 1-phosphate

Keywords

Molecular function 
Isomerase  definition   [KW-0413]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PMM1
GenomeRNAi: 5372
PRO: PR:Q92871