PMM1 - Phosphomannomutase 1 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
PMM1 »  Phosphomannomutase 1   [ EC 5.4.2.8 ]  (PMM 1)
 
Protein also known as:  PMMH-22.
Gene name:  PMM1
Family name: Eukaryotic PMM
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 20 1
GENE REF ISO

Function

 show evidences
Overview 
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain.  
1
  • CuratedUniProtKB
GO molecular function 
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Phosphomannomutase activitydefinition[GO:0004615]  
1
  • IDAUniProtKB
GO biological process 
GDP-mannose biosynthetic processdefinition[GO:0009298]  
  • IEAUniPathway
Mannose biosynthetic processdefinition[GO:0019307] silver  
  • IEAInterPro 2 GO
Mannose metabolic processdefinition[GO:0006013]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5.4.2.8: Alpha-D-mannose 1-phosphate D-mannose 6-phosphate.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium.  
1
  • CuratedUniProtKB
It is regulated in the following manner
IMP, a metabolite whose concentration is elevated in anoxia, inhibits phosphomannomutase and phosphoglucomutase activities and strongly enhances glucose-1,6-bisphosphatase activity (By similarity).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Amino sugar and nucleotide sugar metabolism  hsa00520+5372  
Fructose and mannose metabolism  hsa00051+5372  
Metabolic pathways  hsa01100+5372  
According to Reactome, this protein belongs to the following pathway:
Synthesis of GDP-mannose  REACT_22423  
 

Biophysicochemical properties

Kinetic parameters
KM 54 uM for alpha-D-mannose 1-phosphate
KM 7.5 uM for alpha-D-glucose 1-phosphate

Keywords

Molecular function 
Isomerase  definition   [KW-0413]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PMM1
GenomeRNAi: 5372
PRO: PR:Q92871