KLK6 - Kallikrein-6 - human protein (Function)
 
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KLK6 »  Kallikrein-6   [ EC 3.4.21.- ]
 
Protein also known as:  Serine protease 18.
Gene name:  KLK6
Family name: Peptidase S1 » Kallikrein
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.  
6
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
Serine-type endopeptidase activitydefinition[GO:0004252]  
2
  • IDAUniProtKB
GO biological process 
Amyloid precursor protein metabolic processdefinition[GO:0042982]  
1
  • NASUniProtKB
Central nervous system developmentdefinition[GO:0007417]  
1
  • NASUniProtKB
Collagen catabolic processdefinition[GO:0030574]  
1
  • NASUniProtKB
Hormone metabolic processdefinition[GO:0042445]  
1
  • NASUniProtKB
Myelinationdefinition[GO:0042552]  
1
  • NASUniProtKB
Positive regulation of G-protein coupled receptor protein signaling pathwaydefinition[GO:0045745]  
1
  • IDAUniProtKB
Protein autoprocessingdefinition[GO:0016540]  
1
  • NASUniProtKB
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Regulation of cell differentiationdefinition[GO:0045595]  
1
  • NASUniProtKB
Regulation of neuron projection developmentdefinition[GO:0010975] silver  
  • IEAOrtholog Compara
Response to woundingdefinition[GO:0009611]  
1
  • NASUniProtKB
Tissue regenerationdefinition[GO:0042246]  
1
  • NASUniProtKB
Enzymatic activity 
It is regulated in the following manner
Inhibited by a range of serine protease inhibitors including soybean trypsin inhibitor, benzamidine and serpins. Activated by a range of glycosaminoglycans including chondroitin sulfate, dermatan sulfate, heparan sulfate and heparin.  
2
  • CuratedUniProtKB
 
More information is available from:
 

Biophysicochemical properties

Kinetic parameters
KM 1.72 mM for Val-Leu-Lys-AMC
KM 0.758 mM for Gln-Gly-Arg-AMC
KM 0.625 mM for Pro-Phe-Arg-AMC
KM 777 uM for Tosyl-Gly-Pro-Lys-AMC
KM 0.455 mM for Gly-Gly-Arg-AMC
KM 0.271 mM for Val-Pro-Arg-AMC
KM 1562 uM for Tosyl-Gly-Pro-Arg-AMC
KM 0.335 mM for Asp-Pro-Arg-AMC
KM 0.410 mM for Phe-Ser-Arg-AMC

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q92876
Other
GeneWiki: KLK6
GenomeRNAi: 5653
PRO: PR:Q92876