ABCC2 - Canalicular multispecific organic anion transporter 1 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
ABCC2 »  Canalicular multispecific organic anion transporter 1
 
Protein also known as:  ATP-binding cassette sub-family C member 2.
Gene name:  ABCC2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 172 1
GENE REF ISO

Function

 show evidences
Overview 
Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the atp-binding cassette (abc) superfamily  3.A.1.208.2  
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
ATPase activity, coupled to transmembrane movement of substancesdefinition[GO:0042626] silver  
  • IEAInterPro 2 GO
Organic anion transmembrane transporter activitydefinition[GO:0008514]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein domain specific bindingdefinition[GO:0019904] silver  
  • IEAOrtholog Compara
GO biological process 
ATP catabolic processdefinition[GO:0006200]  
1
  • TASGOC
Cellular chloride ion homeostasisdefinition[GO:0030644] silver  
  • IEAOrtholog Compara
Drug transmembrane transportdefinition[GO:0006855] silver  
  • IEAOrtholog Compara
Ion transmembrane transportdefinition[GO:0034220]  
1
  • TASGOC
Metabolic processdefinition[GO:0008152]  
1
  • TASGOC
Prostaglandin transportdefinition[GO:0015732] silver  
  • IEAOrtholog Compara
Response to arsenic-containing substancedefinition[GO:0046685] silver  
  • IEAOrtholog Compara
Response to estrogendefinition[GO:0043627] silver  
  • IEAOrtholog Compara
Response to heatdefinition[GO:0009408] silver  
  • IEAOrtholog Compara
Response to methotrexatedefinition[GO:0031427] silver  
  • IEAOrtholog Compara
Response to oxidative stressdefinition[GO:0006979] silver  
  • IEAOrtholog Compara
Thyroid hormone transportdefinition[GO:0070327] silver  
  • IEAOrtholog Compara
Transportdefinition[GO:0006810]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
ABC transporters  hsa02010+1244  
Bile secretion  hsa04976+1244  
According to Reactome, this protein belongs to the following pathway:
Transmembrane transport of small molecules  REACT_15518  
 

Keywords

Biological process 
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q92887
Other
GeneWiki: Multidrug_resistance-associated_protein_2
GenomeRNAi: 1244
PRO: PR:Q92887