ARHGEF1 - Rho guanine nucleotide exchange factor 1 - human protein (Function)
 
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Protein
Gene
References

 
ARHGEF1 »  Rho guanine nucleotide exchange factor 1
 
Protein also known as:  115 kDa guanine nucleotide exchange factor (p115RhoGEF).
Gene name:  ARHGEF1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 56 3
GENE REF ISO

Function

 show evidences
Overview 
Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.  
4
  • CuratedUniProtKB
GO molecular function 
GTPase activator activitydefinition[GO:0005096]  
  • IEAUniProtKB KW
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Rho guanyl-nucleotide exchange factor activitydefinition[GO:0005089] silver  
  • IEAInterPro 2 GO
GO biological process 
Cell proliferationdefinition[GO:0008283]  
1
  • TASPINC
Regulation of Rho GTPase activitydefinition[GO:0032319]  
1
  • TASGOC
Rho protein signal transductiondefinition[GO:0007266]  
1
  • TASPINC
Termination of G-protein coupled receptor signaling pathwaydefinition[GO:0038032] silver  
  • IEAInterPro 2 GO
Pathways 
According to KEGG, this protein belongs to the following pathways:
Regulation of actin cytoskeleton  hsa04810+9138  
Vascular smooth muscle contraction  hsa04270+9138  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
GTPase activation  definition   [KW-0343]
Guanine-nucleotide releasing factor  definition   [KW-0344]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ARHGEF1
GenomeRNAi: 9138
PRO: PR:Q92888