CDS1 - Phosphatidate cytidylyltransferase 1 - human protein (Function)
 
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Protein
Gene
References

 
CDS1 »  Phosphatidate cytidylyltransferase 1   [ EC 2.7.7.41 ]
 
Protein also known as:  CTP:phosphatidate cytidylyltransferase 1.
Gene name:  CDS1
Family name: CDS
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol (PtdIns), phosphatidylglycerol, and cardiolipin. Overexpression may amplify cellular signaling responses from cytokines. May also play an important role in the signal transduction mechanism of retina and neural cells.  
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  • UniProtKB
GO molecular function 
Diacylglycerol cholinephosphotransferase activitydefinition[GO:0004142]  
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  • UniProtKB
Phosphatidate cytidylyltransferase activitydefinition[GO:0004605]  
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  • UniProtKB
GO biological process 
CDP-choline pathwaydefinition[GO:0006657]  
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  • GOC
CDP-diacylglycerol biosynthetic processdefinition[GO:0016024]  
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  • UniProtKB
  • UniPathway
Phosphatidylinositol biosynthetic processdefinition[GO:0006661]  
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  • UniProtKB
Phototransductiondefinition[GO:0007602]  
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  • UniProtKB
Signal transductiondefinition[GO:0007165]  
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  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.7.41: CTP + phosphatidate diphosphate + CDP-diacylglycerol.  
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  • UniProtKB
It requires the following cofactor
 Mg(2+)  
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  • UniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3  
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  • UniProtKB
According to KEGG, this protein belongs to the following pathways:
Glycerophospholipid metabolism  hsa00564+1040  
Metabolic pathways  hsa01100+1040  
Phosphatidylinositol signaling system  hsa04070+1040  
According to Reactome, this protein belongs to the following pathway:
Synthesis of PI  REACT_121000  
 

Keywords

Biological process 
Lipid biosynthesis  definition   [KW-0444]
Lipid metabolism  definition   [KW-0443]
Phospholipid biosynthesis  definition   [KW-0594]
Phospholipid metabolism  definition   [KW-1208]
Molecular function 
Nucleotidyltransferase  definition   [KW-0548]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CDS1_(gene)
GenomeRNAi: 1040
PRO: PR:Q92903