DAZL - Deleted in azoospermia-like - human protein (Function)
 
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DAZL »  Deleted in azoospermia-like
 
Protein also known as:  Deleted in azoospermia-like 1.
Gene name:  DAZL
Family name: RRM DAZ
Entry whose protein(s) existence is based on evidence at protein level
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1 41 2
GENE REF ISO

Function

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Overview 
RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Identical protein bindingdefinition[GO:0042802] silver  
  • IEAOrtholog Compara
mRNA 3'-UTR bindingdefinition[GO:0003730] silver  
  • IEAOrtholog Compara
Nucleotide bindingdefinition[GO:0000166] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
RNA bindingdefinition[GO:0003723]  
1
  • TASPINC
Translation activator activitydefinition[GO:0008494]  
1
  • IDAUniProtKB
GO biological process 
Germ cell developmentdefinition[GO:0007281] silver  
  • IEAOrtholog Compara
Multicellular organismal developmentdefinition[GO:0007275]  
  • IEAUniProtKB KW
Positive regulation of meiosisdefinition[GO:0045836] silver  
  • IEAOrtholog Compara
Positive regulation of translational initiationdefinition[GO:0045948]  
1
  • IDAUniProtKB
Spermatogenesisdefinition[GO:0007283]  
  • IEAUniProtKB KW
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Spermatogenesis  definition   [KW-0744]
Translation regulation  definition   [KW-0810]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: DAZL
GenomeRNAi: 1618
PRO: PR:Q92904