COPS5 - COP9 signalosome complex subunit 5 - human protein (Function)
 
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COPS5 »  COP9 signalosome complex subunit 5   [ EC 3.4.-.- ]  (SGN5)
 
Protein also known as:  Jun activation domain-binding protein 1.
Gene name:  COPS5
Family name: Peptidase M67A » CSN5
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2.  
7
  • CuratedUniProtKB
GO molecular function 
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Metallopeptidase activitydefinition[GO:0008237]  
1
  • IMPUniProtKB
Protein bindingdefinition[GO:0005515]  
12
  • IPIIntAct
  • IPIUniProtKB
Transcription coactivator activitydefinition[GO:0003713]  
1
  • TASPINC
Translation initiation factor activitydefinition[GO:0003743]  
1
  • TASPINC
Ubiquitin-specific protease activitydefinition[GO:0004843]  
1
  • IDAFlyBase
GO biological process 
Cullin deneddylationdefinition[GO:0010388]  
1
  • IDAUniProtKB
Exosomal secretiondefinition[GO:1990182]  
1
  • IDAFlyBase
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDAUniProtKB
Protein deneddylationdefinition[GO:0000338]  
1
  • IMPUniProtKB
Protein deubiquitinationdefinition[GO:0016579]  
1
  • IDAFlyBase
Regulation of cell cycledefinition[GO:0051726] silver  
  • IEAOrtholog Compara
Regulation of JNK cascadedefinition[GO:0046328]  
1
  • IDAUniProtKB
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • TASPINC
Translationdefinition[GO:0006412]  
1
  • TASPINC
Translational initiationdefinition[GO:0006413]  
1
  • TASGOC
Enzymatic activity 
It requires the following cofactor
Divalent metal ions (By similarity).  
  • CuratedUniProtKB
 
More information is available from:
Note 
The CSN complex is associated with some 'Lys-63'-specific deubiquitination. Such activity is however not mediated by the core CSN complex but by the BRCC3/BRCC36 component of the BRISC complex.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 10987
PRO: PR:Q92905