GATA6 - Transcription factor GATA-6 - human protein (Function)
 
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GATA6 »  Transcription factor GATA-6
 
Protein also known as:  GATA-binding factor 6.
Gene name:  GATA6
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Transcriptional activator that regulates SEMA3C and PLXNA2. Thought to be important for regulating terminal differentiation and/or proliferation. Involved in gene regulation specifically in the gastric epithelium. Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity).  
1
  • UniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
3
  • UniProtKB
Protein kinase bindingdefinition[GO:0019901]  
1
  • UniProtKB
RNA polymerase II core promoter sequence-specific DNA bindingdefinition[GO:0000979] silver  
1
  • Ortholog Compara
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activitydefinition[GO:0003705] silver  
1
  • Ortholog Compara
RNA polymerase II repressing transcription factor bindingdefinition[GO:0001103] silver  
1
  • Ortholog Compara
Sequence-specific DNA binding RNA polymerase II transcription factor activitydefinition[GO:0000981]  
1
  • UniProtKB
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
2
  • UniProtKB
  • BHF-UCL
Transcription factor bindingdefinition[GO:0008134]  
2
  • BHF-UCL
  • UniProtKB
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
4
  • UniProtKB
  • BHF-UCL
  • MGI
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
Cardiac muscle cell differentiationdefinition[GO:0055007] silver  
1
  • Ortholog Compara
Cardiac muscle hypertrophy in response to stressdefinition[GO:0014898] silver  
1
  • Ortholog Compara
Cardiac vascular smooth muscle cell differentiationdefinition[GO:0060947]  
2
  • UniProtKB
Cellular response to BMP stimulusdefinition[GO:0071773] silver  
1
  • Ortholog Compara
Cellular response to gonadotropin stimulusdefinition[GO:0071371] silver  
1
  • Ortholog Compara
Cellular response to hypoxiadefinition[GO:0071456]  
1
  • UniProtKB
Clara cell differentiationdefinition[GO:0060486] silver  
1
  • Ortholog Compara
Endodermal cell fate determinationdefinition[GO:0007493] silver  
1
  • Ortholog Compara
In utero embryonic developmentdefinition[GO:0001701] silver  
1
  • Ortholog Compara
Intestinal epithelial cell differentiationdefinition[GO:0060575]  
1
  • MGI
Liver developmentdefinition[GO:0001889] silver  
1
  • Ortholog Compara
Lung saccule developmentdefinition[GO:0060430] silver  
1
  • Ortholog Compara
Male gonad developmentdefinition[GO:0008584]  
1
  • UniProtKB
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • UniProtKB
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • UniProtKB
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • UniProtKB
Negative regulation of transforming growth factor beta1 productiondefinition[GO:0032911]  
1
  • UniProtKB
Negative regulation of transforming growth factor beta2 productiondefinition[GO:0032912]  
1
  • UniProtKB
Organ formationdefinition[GO:0048645] silver  
1
  • Ortholog Compara
Outflow tract septum morphogenesisdefinition[GO:0003148]  
1
  • BHF-UCL
Pancreatic A cell differentiationdefinition[GO:0003310] silver  
1
  • Ortholog Compara
Phospholipid metabolic processdefinition[GO:0006644] silver  
1
  • Ortholog Compara
Positive regulation of angiogenesisdefinition[GO:0045766]  
1
  • UniProtKB
Positive regulation of cardiac muscle cell proliferationdefinition[GO:0060045] silver  
1
  • Ortholog Compara
Positive regulation of cardioblast differentiationdefinition[GO:0051891] silver  
1
  • Ortholog Compara
Positive regulation of cell cycle arrestdefinition[GO:0071158]  
1
  • UniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • UniProtKB
  • Ortholog Compara
Response to drugdefinition[GO:0042493]  
1
  • UniProtKB
Response to estrogendefinition[GO:0043627] silver  
1
  • Ortholog Compara
Response to growth factordefinition[GO:0070848]  
1
  • UniProtKB
Smooth muscle cell differentiationdefinition[GO:0051145]  
1
  • UniProtKB
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • BHF-UCL
Type B pancreatic cell differentiationdefinition[GO:0003309] silver  
1
  • Ortholog Compara
Type II pneumocyte differentiationdefinition[GO:0060510] silver  
1
  • Ortholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathway:
Factors involved in megakaryocyte development and platelet production  REACT_24970  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GATA6
GenomeRNAi: 2627
PRO: PR:Q92908