GCDH - Glutaryl-CoA dehydrogenase, mitochondrial - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
GCDH »  Glutaryl-CoA dehydrogenase, mitochondrial
 
Gene name:  GCDH
Family name: Acyl-CoA dehydrogenase
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 43 2
GENE REF ISO

Function

 show evidences
Overview 
Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor.  
2
  • CuratedUniProtKB
Isoform  Short   Is inactive.  
2
  • CuratedUniProtKB
GO molecular function 
Fatty-acyl-CoA bindingdefinition[GO:0000062] silver  
  • IEAOrtholog Compara
Flavin adenine dinucleotide bindingdefinition[GO:0050660] silver  
  • IEAOrtholog Compara
GO biological process 
Fatty acid oxidationdefinition[GO:0019395] silver  
  • IEAOrtholog Compara
Fatty-acyl-CoA biosynthetic processdefinition[GO:0046949] silver  
  • IEAOrtholog Compara
Tryptophan metabolic processdefinition[GO:0006568]  
  • IEAUniPathway
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.3.8.6: Glutaryl-CoA + electron-transfer flavoprotein crotonyl-CoA + CO(2) + reduced electron-transfer flavoprotein.  
  • CuratedUniProtKB
It requires the following cofactor
FAD.  
  • CuratedUniProtKB
It is regulated in the following manner
Strongly inhibited by MCPA-CoA, a metabolite of hypoglycin which is present in unripened fruit of the ackee tree.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathways
According to KEGG, this protein belongs to the following pathways:
Fatty acid metabolism  hsa00071+2639  
Lysine degradation  hsa00310+2639  
Metabolic pathways  hsa01100+2639  
Tryptophan metabolism  hsa00380+2639  
According to Reactome, this protein belongs to the following pathway:
Lysine catabolism  REACT_1298  
 

Biophysicochemical properties

Kinetic parameters
Release of crotonyl-CoA product from the enzyme is the rate-determining step in its steady-state turnover.
KM 8.1 uM for glutaryl-CoA (at pH 7.6)
KM 34.0 uM for glutaryl-CoA (at pH 8.5)
KM 5.5 uM for glutaryl-CoA (at pH 7.5)
KM 4.7 uM for glutaryl-CoA (at pH 6.5)

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q92947
Other
GenomeRNAi: 2639
PRO: PR:Q92947