KCNN1 - Small conductance calcium-activated potassium channel protein 1 - human protein (Function)
 
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Protein
Gene
References

 
KCNN1 »  Small conductance calcium-activated potassium channel protein 1  (SK1)
 
Protein also known as:  KCa2.1.
Gene name:  KCNN1
Entry whose protein(s) existence is based on evidence at transcript level
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1 12 2
GENE REF ISO

Function

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Overview 
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Calcium-activated potassium channel activitydefinition[GO:0015269]  
1
  • TASPINC
Calmodulin bindingdefinition[GO:0005516] silver  
  • IBARefGenome
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IEAOrtholog Compara
Small conductance calcium-activated potassium channel activitydefinition[GO:0016286] silver  
  • IBARefGenome
GO biological process 
Potassium ion transmembrane transportdefinition[GO:0071805] silver  
  • IBARefGenome
Potassium ion transportdefinition[GO:0006813]  
1
  • TASPINC
Pathways 
According to Reactome, this protein belongs to the following pathway:
Neuronal System  REACT_13685  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: KCNN1
GenomeRNAi: 3780
PRO: PR:Q92952
Chemistry
GuidetoPHARMACOLOGY: 381