KCNB2 - Potassium voltage-gated channel subfamily B member 2 - human protein (Function)
 
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KCNB2 »  Potassium voltage-gated channel subfamily B member 2
 
Protein also known as:  Voltage-gated potassium channel subunit Kv2.2.
Gene name:  KCNB2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNS1 and KCNS2, creating a functionally diverse range of channel complexes. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells.  
3
  • UniProtKB
GO molecular function 
Delayed rectifier potassium channel activitydefinition[GO:0005251]  
1
  • Ortholog Curator
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • Ortholog Curator
GO biological process 
Potassium ion transmembrane transportdefinition[GO:0071805]  
2
  • Ortholog Curator
  • RefGenome
Potassium ion transportdefinition[GO:0006813]  
1
  • Ortholog Curator
Protein homooligomerizationdefinition[GO:0051260] silver  
1
  • InterPro 2 GO
Protein targeting to plasma membranedefinition[GO:0072661]  
1
  • Ortholog Curator
Regulation of ion transmembrane transportdefinition[GO:0034765]  
1
  • UniProtKB KW
Regulation of smooth muscle contractiondefinition[GO:0006940]  
1
  • PINC
Enzymatic activity 
It is regulated in the following manner
Inhibited by quinine at micromolar levels. Modestly sensitive to millimolar levels of tetraethylammonium (TEA) and 4-aminopyridine (4-AP).  
4
  • UniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Voltage gated Potassium channels  R-HSA-1296072  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Potassium channel  definition   [KW-0631]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: KCNB2
GenomeRNAi: 9312
PRO: PR:Q92953
Chemistry
GuidetoPHARMACOLOGY: 547