CD101 - Immunoglobulin superfamily member 2 - human protein (Function)
 
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CD101 »  Immunoglobulin superfamily member 2  (IgSF2)
 
Protein also known as:  Glu-Trp-Ile EWI motif-containing protein 101 (EWI-101); CD antigen CD101.
Gene name:  CD101
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4(+) CD56(+) leukemic tumor cells.  
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  • CuratedUniProtKB
GO molecular function 
Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidesdefinition[GO:0016812] silver  
  • IEAInterPro 2 GO
GO biological process 
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • TASPINC
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: IGSF2
GenomeRNAi: 9398
PRO: PR:Q93033