ATP6V0A1 - V-type proton ATPase 116 kDa subunit a isoform 1 - human protein (Function)
 
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ATP6V0A1 »  V-type proton ATPase 116 kDa subunit a isoform 1  (V-ATPase 116 kDa isoform a1)
 
Protein also known as:  Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit.
Gene name:  ATP6V0A1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 31 3
GENE REF ISO

Function

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Overview 
Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity).  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily  3.A.2.2.4  
GO molecular function 
ATPase bindingdefinition[GO:0051117]  
1
  • IPIUniProtKB
Hydrogen ion transmembrane transporter activitydefinition[GO:0015078] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
1
  • IPIHGNC
GO biological process 
ATP hydrolysis coupled proton transportdefinition[GO:0015991] silver  
  • IEAInterPro 2 GO
Pathways 
According to KEGG, this protein belongs to the following pathways:
Collecting duct acid secretion  hsa04966+535  
Epithelial cell signaling in Helicobacter pylori infection  hsa05120+535  
Lysosome  hsa04142+535  
Metabolic pathways  hsa01100+535  
Oxidative phosphorylation  hsa00190+535  
Phagosome  hsa04145+535  
Rheumatoid arthritis  hsa05323+535  
Synaptic vesicle cycle  hsa04721+535  
Tuberculosis  hsa05152+535  
Vibrio cholerae infection  hsa05110+535  
According to Reactome, this protein belongs to the following pathways:
Insulin receptor recycling  REACT_1109  
Phagosomal maturation (early endosomal stage)  REACT_121256  
Transferrin endocytosis and recycling  REACT_25283  
 
More information is available from:
 

Keywords

Biological process 
Hydrogen ion transport  definition   [KW-0375]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links