EXT2 - Exostosin-2 - human protein (Function)
 
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Protein
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EXT2 »  Exostosin-2   [ EC 2.4.1.224EC 2.4.1.225 ]
 
Protein also known as:  Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase.
Gene name:  EXT2
Family name: Glycosyltransferase 47
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor.  
  • CuratedUniProtKB
GO molecular function 
Contributes to acetylglucosaminyltransferase activitydefinition[GO:0008375]  
1
  • IDABHF-UCL
Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activitydefinition[GO:0050508]  
  • IEAEC 2 GO
Glucuronosyltransferase activitydefinition[GO:0015020]  
1
  • IDABHF-UCL
Heparan sulfate N-acetylglucosaminyltransferase activitydefinition[GO:0042328]  
1
  • NASBHF-UCL
N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activitydefinition[GO:0050509]  
1
  • NASBHF-UCL
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • IPIBHF-UCL
Not  Protein homodimerization activitydefinition[GO:0042803]  
1
  • IDABHF-UCL
Transferase activity, transferring glycosyl groupsdefinition[GO:0016757]  
1
  • IDABHF-UCL
GO biological process 
Cell differentiationdefinition[GO:0030154] silver  
  • IEAOrtholog Compara
Cellular polysaccharide biosynthetic processdefinition[GO:0033692]  
1
  • IDABHF-UCL
Glycosaminoglycan biosynthetic processdefinition[GO:0006024]  
1
  • IDABHF-UCL
Heparan sulfate proteoglycan biosynthetic processdefinition[GO:0015012]  
1
  • IMPBHF-UCL
Heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic processdefinition[GO:0015014]  
1
  • IMPBHF-UCL
Mesoderm formationdefinition[GO:0001707] silver  
  • IEAOrtholog Compara
Ossificationdefinition[GO:0001503]  
1
  • IMPBHF-UCL
Protein glycosylationdefinition[GO:0006486]  
  • IEAUniPathway
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 2.4.1.224: UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan UDP + N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan.  
  • CuratedUniProtKB
EC 2.4.1.225: UDP-alpha-D-glucuronate + N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan UDP + beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan.  
  • CuratedUniProtKB
According to CAZy, this protein is belongs to the following pathways:
Glycosyltransferase Family 47  GT47  
Glycosyltransferase Family 64  GT64  
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Glycosaminoglycan biosynthesis - heparan sulfate  hsa00534+2132  
Metabolic pathways  hsa01100+2132  
According to Reactome, this protein belongs to the following pathway:
HS-GAG biosynthesis  REACT_121248  
 
More information is available from:
 

Keywords

Molecular function 
Glycosyltransferase  definition   [KW-0328]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: EXT2_(gene)
GenomeRNAi: 2132
PRO: PR:Q93063