MED12 - Mediator of RNA polymerase II transcription subunit 12 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
MED12 »  Mediator of RNA polymerase II transcription subunit 12
 
Protein also known as:  Thyroid hormone receptor-associated protein complex 230 kDa component (Trap230).
Gene name:  MED12
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 84 3
GENE REF ISO

Function

 show evidences
Overview 
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway.  
3
  • CuratedUniProtKB
GO molecular function 
Beta-catenin bindingdefinition[GO:0008013] silver  
  • IEAInterPro 2 GO
Chromatin bindingdefinition[GO:0003682] silver  
  • IEAOrtholog Compara
Ligand-dependent nuclear receptor transcription coactivator activitydefinition[GO:0030374]  
1
  • NASUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Protein C-terminus bindingdefinition[GO:0008022]  
1
  • IPIUniProtKB
Protein domain specific bindingdefinition[GO:0019904]  
1
  • IPIUniProtKB
Receptor activitydefinition[GO:0004872]  
1
  • IDAUniProtKB
RNA polymerase II distal enhancer sequence-specific DNA bindingdefinition[GO:0000980] silver  
  • IEAOrtholog Compara
RNA polymerase II transcription cofactor activitydefinition[GO:0001104]  
1
  • IDAUniProtKB
RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001190] silver  
  • IEAOrtholog Compara
Thyroid hormone receptor bindingdefinition[GO:0046966]  
1
  • IDAUniProtKB
Transcription coactivator activitydefinition[GO:0003713]  
1
  • IDAMGI
Transcription cofactor activitydefinition[GO:0003712]  
1
  • IDAUniProtKB
Vitamin D receptor bindingdefinition[GO:0042809]  
1
  • NASUniProtKB
GO biological process 
Androgen receptor signaling pathwaydefinition[GO:0030521]  
1
  • IDAUniProtKB
Axis elongation involved in somitogenesisdefinition[GO:0090245] silver  
  • IEAOrtholog Compara
Canonical Wnt signaling pathwaydefinition[GO:0060070] silver  
  • IEAOrtholog Compara
Heart developmentdefinition[GO:0007507] silver  
  • IEAOrtholog Compara
Intracellular steroid hormone receptor signaling pathwaydefinition[GO:0030518]  
1
  • IDAUniProtKB
Negative regulation of Wnt signaling pathwaydefinition[GO:0030178]  
1
  • IMPUniProtKB
Neural tube closuredefinition[GO:0001843] silver  
  • IEAOrtholog Compara
Oligodendrocyte developmentdefinition[GO:0014003] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDAMGI
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDAUniProtKB
Schwann cell developmentdefinition[GO:0014044] silver  
  • IEAOrtholog Compara
Stem cell maintenancedefinition[GO:0019827] silver  
  • IEAOrtholog Compara
Transcription initiation from RNA polymerase II promoterdefinition[GO:0006367]  
1
  • IDAUniProtKB
Wnt signaling pathway, planar cell polarity pathwaydefinition[GO:0060071] silver  
  • IEAOrtholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathways:
Developmental Biology  REACT_111045  
Gene Expression  REACT_71  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MED12
GenomeRNAi: 9968
PRO: PR:Q93074