ATP2A3 - Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 - human protein (Function)
 
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ATP2A3 »  Sarcoplasmic/endoplasmic reticulum calcium ATPase 3   [ EC 3.6.3.8 ]  (SERCA3)
 
Protein also known as:  Calcium pump 3.
Gene name:  ATP2A3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.  
2
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Calcium-transporting ATPase activitydefinition[GO:0005388]  
  • IEAEC 2 GO
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
GO biological process 
Calcium ion transmembrane transportdefinition[GO:0070588]  
1
  • TASGOC
  • IEAEC 2 GO
  • IEAInterPro 2 GO
Calcium ion transportdefinition[GO:0006816]  
1
  • TASUniProtKB
Metabolic processdefinition[GO:0008152]  
  • IEAUniProtKB KW
Transportdefinition[GO:0006810]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.3.8: ATP + H(2)O + Ca(2+)(Side 1) ADP + phosphate + Ca(2+)(Side 2).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+489  
Calcium signaling pathway  hsa04020+489  
Pancreatic secretion  hsa04972+489  
According to Reactome, this protein belongs to the following pathways:
Ion transport by P-type ATPases  REACT_25149  
Pre-NOTCH Processing in Golgi  REACT_118798  
Reduction of cytosolic Ca++ levels  REACT_23765  
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ATP2A3
GenomeRNAi: 489
PRO: PR:Q93084