PHKB - Phosphorylase b kinase regulatory subunit beta - human protein (Function)
 
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PHKB »  Phosphorylase b kinase regulatory subunit beta  (Phosphorylase kinase subunit beta)
 
Gene name:  PHKB
Entry whose protein(s) existence is based on evidence at protein level
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1 36 4
GENE REF ISO

Function

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Overview 
Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The beta chain acts as a regulatory unit and modulates the activity of the holoenzyme in response to phosphorylation.  
  • CuratedUniProtKB
GO molecular function 
Calmodulin bindingdefinition[GO:0005516]  
  • IEAUniProtKB KW
Hydrolase activity, hydrolyzing O-glycosyl compoundsdefinition[GO:0004553] silver  
  • IEAInterPro 2 GO
Phosphorylase kinase activitydefinition[GO:0004689] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
GO biological process 
Generation of precursor metabolites and energydefinition[GO:0006091]  
1
  • TASPINC
Glycogen metabolic processdefinition[GO:0005977]  
1
  • TASPINC
Protein phosphorylationdefinition[GO:0006468]  
  • IEAOrtholog Compara
Enzymatic activity 
It is regulated in the following manner
By phosphorylation of various serine residues (By similarity).  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+5257  
Insulin signaling pathway  hsa04910+5257  
According to Reactome, this protein belongs to the following pathway:
Glycogen breakdown (glycogenolysis)  REACT_1008  
 
More information is available from:
 

Keywords

Biological process 
Carbohydrate metabolism  definition   [KW-0119]
Glycogen metabolism  definition   [KW-0321]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PHKB
GenomeRNAi: 5257
PRO: PR:Q93100