SMARCE1 - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 - human protein (Function)
 
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SMARCE1 »  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
 
Protein also known as:  BRG1-associated factor 57 (BAF57).
Gene name:  SMARCE1
Entry whose protein(s) existence is based on evidence at protein level
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1 47 6
GENE REF ISO

Function

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Overview 
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Required for the coactivation of estrogen responsive promoters by Swi/Snf complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.  
1
  • CuratedUniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682]  
1
  • TASPINC
DNA bindingdefinition[GO:0003677]  
  • IEAUniProtKB KW
Ligand-dependent nuclear receptor bindingdefinition[GO:0016922]  
1
  • IPIBHF-UCL
N-acetyltransferase activitydefinition[GO:0008080]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
6
  • IPIBHF-UCL
  • IPIIntAct
  • IPIUniProtKB
Protein N-terminus bindingdefinition[GO:0047485]  
1
  • IPIUniProtKB
RNA bindingdefinition[GO:0003723] silver  
  • IEAOrtholog Compara
Transcription coactivator activitydefinition[GO:0003713]  
1
  • NASBHF-UCL
GO biological process 
Chromatin remodelingdefinition[GO:0006338]  
1
  • IDABHF-UCL
Metabolic processdefinition[GO:0008152]  
1
  • IDAGOC
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IDAUniProtKB
Nervous system developmentdefinition[GO:0007399]  
  • IEAUniProtKB KW
Nucleosome disassemblydefinition[GO:0006337]  
1
  • IDABHF-UCL
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • NASBHF-UCL
 

Keywords

Biological process 
Neurogenesis  definition   [KW-0524]
Molecular function 
Chromatin regulator  definition   [KW-0156]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SMARCE1
GenomeRNAi: 6605
PRO: PR:Q969G3