FBXW7 - F-box/WD repeat-containing protein 7 - human protein (Function)
 
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FBXW7 »  F-box/WD repeat-containing protein 7
 
Protein also known as:  F-box and WD-40 domain-containing protein 7.
Gene name:  FBXW7
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 176 4
GENE REF ISO

Function

 show evidences
Overview 
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.  
5
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
9
  • IPIIntAct
  • IPIUniProtKB
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAOrtholog Compara
GO biological process 
Isoform  Iso 1   Cellular response to DNA damage stimulusdefinition[GO:0006974]  
1
  • IDAUniProtKB
Isoform  Iso 1   Cellular response to UVdefinition[GO:0034644]  
1
  • IDAUniProtKB
Lipid homeostasisdefinition[GO:0055088]  
  • ISSOrtholog Curator
Lung developmentdefinition[GO:0030324] silver  
  • IEAOrtholog Compara
Negative regulation of DNA endoreduplicationdefinition[GO:0032876]  
1
  • IMPBHF-UCL
Negative regulation of hepatocyte proliferationdefinition[GO:2000346]  
  • ISSOrtholog Curator
Negative regulation of Notch signaling pathwaydefinition[GO:0045746]  
  • ISSOrtholog Curator
Negative regulation of SREBP signaling pathwaydefinition[GO:2000639]  
  • ISSOrtholog Curator
Negative regulation of triglyceride biosynthetic processdefinition[GO:0010868]  
  • ISSOrtholog Curator
Positive regulation of epidermal growth factor-activated receptor activitydefinition[GO:0045741]  
1
  • IDABHF-UCL
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
1
  • IMPBHF-UCL
Positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic processdefinition[GO:2000060]  
1
  • IDABHF-UCL
Protein stabilizationdefinition[GO:0050821]  
1
  • IDABHF-UCL
Protein ubiquitinationdefinition[GO:0016567]  
2
  • IDAUniProtKB
  • IDAMGI
Regulation of lipid storagedefinition[GO:0010883]  
  • ISSOrtholog Curator
Regulation of protein localizationdefinition[GO:0032880]  
  • ISSOrtholog Curator
SCF-dependent proteasomal ubiquitin-dependent protein catabolic processdefinition[GO:0031146]  
1
  • IDAUniProtKB
Sister chromatid cohesiondefinition[GO:0007062]  
1
  • IMPBHF-UCL
Vasculature developmentdefinition[GO:0001944]  
1
  • TASBHF-UCL
Vasculogenesisdefinition[GO:0001570] silver  
  • IEAOrtholog Compara
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathway:
Ubiquitin mediated proteolysis  hsa04120+55294  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Immune System  REACT_6900  
Metabolism of proteins  REACT_17015  
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Ubl conjugation pathway  definition   [KW-0833]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FBXW7
GenomeRNAi: 55294
PRO: PR:Q969H0