FBXW7 - F-box/WD repeat-containing protein 7 - human protein (Function)
 
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FBXW7 »  F-box/WD repeat-containing protein 7
 
Protein also known as:  F-box and WD-40 domain-containing protein 7.
Gene name:  FBXW7
Entry whose protein(s) existence is based on evidence at protein level
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1 200 4
GENE REF ISO

Function

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Overview 
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.  
6
  • UniProtKB
GO molecular function 
Cyclin bindingdefinition[GO:0030332]  
1
  • ParkinsonsUK-UCL
Identical protein bindingdefinition[GO:0042802]  
2
  • IntAct
Protein bindingdefinition[GO:0005515]  
10
  • IntAct
  • UniProtKB
Protein binding, bridgingdefinition[GO:0030674]  
1
  • ParkinsonsUK-UCL
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
1
  • Ortholog Compara
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • ParkinsonsUK-UCL
Ubiquitin-protein transferase activator activitydefinition[GO:0097027]  
1
  • ParkinsonsUK-UCL
GO biological process 
Isoform  Iso 1   Cellular response to DNA damage stimulusdefinition[GO:0006974]  
1
  • UniProtKB
Isoform  Iso 1   Cellular response to UVdefinition[GO:0034644]  
1
  • UniProtKB
Lipid homeostasisdefinition[GO:0055088]  
1
  • Ortholog Curator
Lung developmentdefinition[GO:0030324] silver  
1
  • Ortholog Compara
Negative regulation of DNA endoreduplicationdefinition[GO:0032876]  
1
  • BHF-UCL
Negative regulation of hepatocyte proliferationdefinition[GO:2000346]  
1
  • Ortholog Curator
Negative regulation of Notch signaling pathwaydefinition[GO:0045746]  
1
  • Ortholog Curator
Negative regulation of SREBP signaling pathwaydefinition[GO:2000639]  
1
  • Ortholog Curator
Negative regulation of triglyceride biosynthetic processdefinition[GO:0010868]  
1
  • Ortholog Curator
Positive regulation of epidermal growth factor-activated receptor activitydefinition[GO:0045741]  
1
  • BHF-UCL
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
1
  • BHF-UCL
Positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathwaydefinition[GO:1903378]  
1
  • ParkinsonsUK-UCL
Positive regulation of proteasomal protein catabolic processdefinition[GO:1901800]  
1
  • ParkinsonsUK-UCL
Positive regulation of protein ubiquitinationdefinition[GO:0031398]  
1
  • ParkinsonsUK-UCL
Positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic processdefinition[GO:2000060]  
1
  • BHF-UCL
Positive regulation of ubiquitin-protein transferase activitydefinition[GO:0051443]  
1
  • ParkinsonsUK-UCL
Protein stabilizationdefinition[GO:0050821]  
1
  • BHF-UCL
Protein ubiquitinationdefinition[GO:0016567]  
2
  • UniProtKB
  • MGI
Regulation of cell cycle G1/S phase transitiondefinition[GO:1902806]  
1
  • ParkinsonsUK-UCL
Regulation of lipid storagedefinition[GO:0010883]  
1
  • Ortholog Curator
Regulation of protein localizationdefinition[GO:0032880]  
1
  • Ortholog Curator
Regulation of transcription, DNA-templateddefinition[GO:0006355] silver  
1
  • Ortholog Compara
SCF-dependent proteasomal ubiquitin-dependent protein catabolic processdefinition[GO:0031146]  
1
  • UniProtKB
Sister chromatid cohesiondefinition[GO:0007062]  
1
  • BHF-UCL
Vasculature developmentdefinition[GO:0001944]  
1
  • BHF-UCL
Vasculogenesisdefinition[GO:0001570] silver  
1
  • Ortholog Compara
Viral processdefinition[GO:0016032]  
1
  • UniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathway:
Ubiquitin mediated proteolysis  hsa04120+55294  
According to Reactome, this protein belongs to the following pathways:
Antigen processing: Ubiquitination & Proteasome degradation  REACT_75842  
Association of TriC/CCT with target proteins during biosynthesis  REACT_16907  
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants  REACT_160254  
Constitutive Signaling by NOTCH1 PEST Domain Mutants  REACT_160243  
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling  REACT_160305  
NOTCH1 Intracellular Domain Regulates Transcription  REACT_118780  
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Ubl conjugation pathway  definition   [KW-0833]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FBXW7
GenomeRNAi: 55294
PRO: PR:Q969H0