ADIPOR1 - Adiponectin receptor protein 1 - human protein (Function)
 
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ADIPOR1 »  Adiponectin receptor protein 1
 
Protein also known as:  Progestin and adipoQ receptor family member I.
Gene name:  ADIPOR1
Family name: ADIPOR
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 31 1
GENE REF ISO

Function

 show evidences
Overview 
Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed25855295, PubMed12802337). Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity).  
4
  • UniProtKB
GO molecular function 
Adipokinetic hormone receptor activitydefinition[GO:0097003]  
1
  • UniProtKB
Adiponectin bindingdefinition[GO:0055100]  
1
  • UniProtKB
Identical protein bindingdefinition[GO:0042802] silver  
1
  • Ortholog Compara
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Protein heterodimerization activitydefinition[GO:0046982] silver  
1
  • Ortholog Compara
Protein kinase bindingdefinition[GO:0019901]  
1
  • BHF-UCL
Receptor activitydefinition[GO:0004872]  
1
  • RefGenome
GO biological process 
Adiponectin-activated signaling pathwaydefinition[GO:0033211]  
2
  • UniProtKB
  • RefGenome
Fatty acid oxidationdefinition[GO:0019395]  
1
  • UniProtKB
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • GOC
Glucose homeostasisdefinition[GO:0042593]  
1
  • Ortholog Curator
Hormone-mediated signaling pathwaydefinition[GO:0009755]  
1
  • UniProtKB
Leptin-mediated signaling pathwaydefinition[GO:0033210] silver  
1
  • Ortholog Compara
Negative regulation of cell growthdefinition[GO:0030308] silver  
1
  • Ortholog Compara
Positive regulation of insulin receptor signaling pathwaydefinition[GO:0046628] silver  
1
  • Ortholog Compara
Positive regulation of JAK-STAT cascadedefinition[GO:0046427] silver  
1
  • Ortholog Compara
Regulation of glucose metabolic processdefinition[GO:0010906]  
1
  • Ortholog Curator
Regulation of lipid metabolic processdefinition[GO:0019216]  
1
  • Ortholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathway:
Adipocytokine signaling pathway  hsa04920+51094  
 

Keywords

Biological process 
Fatty acid metabolism  definition   [KW-0276]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: ADIPOR1
GenomeRNAi: 51094
PRO: PR:Q96A54
Chemistry
GuidetoPHARMACOLOGY: 649