ADIPOR1 - Adiponectin receptor protein 1 - human protein (Function)
 
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ADIPOR1 »  Adiponectin receptor protein 1
 
Protein also known as:  Progestin and adipoQ receptor family member I.
Gene name:  ADIPOR1
Family name: ADIPOR
Entry whose protein(s) existence is based on evidence at protein level
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1 26 1
GENE REF ISO

Function

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Overview 
Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length adiponectin.  
1
  • CuratedUniProtKB
GO molecular function 
Hormone bindingdefinition[GO:0042562]  
1
  • IDAUniProtKB
Identical protein bindingdefinition[GO:0042802] silver  
  • IEAOrtholog Compara
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IEAOrtholog Compara
Protein kinase bindingdefinition[GO:0019901]  
1
  • IPIBHF-UCL
Receptor activitydefinition[GO:0004872] silver  
  • IBARefGenome
GO biological process 
Adiponectin-activated signaling pathwaydefinition[GO:0033211] silver  
  • IBARefGenome
Fatty acid oxidationdefinition[GO:0019395]  
1
  • IDAUniProtKB
Hormone-mediated signaling pathwaydefinition[GO:0009755]  
1
  • IDAUniProtKB
Leptin-mediated signaling pathwaydefinition[GO:0033210] silver  
  • IEAOrtholog Compara
Negative regulation of cell growthdefinition[GO:0030308] silver  
  • IEAOrtholog Compara
Positive regulation of insulin receptor signaling pathwaydefinition[GO:0046628] silver  
  • IEAOrtholog Compara
Positive regulation of JAK-STAT cascadedefinition[GO:0046427] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Adipocytokine signaling pathway  hsa04920+51094  
 

Keywords

Biological process 
Fatty acid metabolism  definition   [KW-0276]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: ADIPOR1
GenomeRNAi: 51094
PRO: PR:Q96A54
Chemistry
GuidetoPHARMACOLOGY: 649