ADC - Arginine decarboxylase - human protein (Function)
 
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ADC »  Arginine decarboxylase   [ EC 4.1.1.19 ]  (ADC)
 
Protein also known as:  Ornithine decarboxylase-like protein.
Gene name:  ADC
Entry whose protein(s) existence is based on evidence at transcript level
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GENE REF ISO

Function

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Overview 
Decarboxylates L-arginine to agmatine. Truncated splice isoforms probably lack activity.  
1
  • CuratedUniProtKB
GO molecular function 
Arginine decarboxylase activitydefinition[GO:0008792]  
  • IEAEC 2 GO
Ornithine decarboxylase activator activitydefinition[GO:0042978]  
1
  • IDAUniProtKB
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Putrescine transmembrane transporter activitydefinition[GO:0015489]  
  • ISSOrtholog Curator
GO biological process 
Negative regulation of protein catabolic processdefinition[GO:0042177]  
1
  • IDAUniProtKB
  • ISSOrtholog Curator
Ornithine metabolic processdefinition[GO:0006591] silver  
  • IEAOrtholog Compara
Polyamine biosynthetic processdefinition[GO:0006596]  
  • IEAUniProtKB KW
Positive regulation of catalytic activitydefinition[GO:0043085]  
  • ISSOrtholog Curator
Positive regulation of polyamine transmembrane transportdefinition[GO:1902269]  
  • ISSOrtholog Curator
Putrescine transportdefinition[GO:0015847]  
  • ISSOrtholog Curator
Spermatogenesisdefinition[GO:0007283]  
1
  • NASUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.1.1.19: L-arginine agmatine + CO(2).  
  • CuratedUniProtKB
It requires the following cofactor
Pyridoxal phosphate (By similarity).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Arginine and proline metabolism  hsa00330+113451  
Metabolic pathways  hsa01100+113451  
According to Reactome, this protein belongs to the following pathway:
Agmatine biosynthesis  REACT_14800  
 
More information is available from:
 

Keywords

Biological process 
Polyamine biosynthesis  definition   [KW-0620]
Molecular function 
Decarboxylase  definition   [KW-0210]
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ADC_(gene)
GenomeRNAi: 113451
PRO: PR:Q96A70