AZIN2 - Antizyme inhibitor 2 - human protein (Function)
 
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AZIN2 »  Antizyme inhibitor 2  (AzI2)
 
Protein also known as:  Ornithine decarboxylase-like protein (ODC-like protein).
Gene name:  AZIN2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Antizyme inhibitor protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake by counteracting the negative effect of antizymes OAZ1, OAZ2 and OAZ3 on ODC1 activity (PubMed17900240). Inhibits antizyme-dependent ODC1 degradation by binding to antizymes. Releases ODC1 from its inactive complex with antizymes, leading to formation of the catalytically active ODC1. Participates in the morphological integrity of the trans-Golgi network (TGN) and functions as a regulator of intracellular secretory vesicle trafficking (PubMed20188728).  
4
  • UniProtKB
GO molecular function 
Catalytic activitydefinition[GO:0003824] silver  
1
  • InterPro 2 GO
Ornithine decarboxylase activator activitydefinition[GO:0042978]  
2
  • UniProtKB
  • Ortholog Curator
Protein bindingdefinition[GO:0005515]  
1
  • UniProtKB
Putrescine transmembrane transporter activitydefinition[GO:0015489]  
1
  • Ortholog Curator
GO biological process 
Negative regulation of protein catabolic processdefinition[GO:0042177]  
2
  • UniProtKB
  • Ortholog Curator
Ornithine metabolic processdefinition[GO:0006591] silver  
1
  • Ortholog Compara
Polyamine biosynthetic processdefinition[GO:0006596]  
1
  • UniProtKB KW
Positive regulation of catalytic activitydefinition[GO:0043085]  
1
  • Ortholog Curator
Positive regulation of polyamine transmembrane transportdefinition[GO:1902269]  
1
  • Ortholog Curator
Putrescine transportdefinition[GO:0015847]  
1
  • Ortholog Curator
Spermatogenesisdefinition[GO:0007283]  
1
  • UniProtKB
Trans-Golgi network membrane organizationdefinition[GO:0098629]  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Arginine and proline metabolism  hsa00330+113451  
Metabolic pathways  hsa01100+113451  
According to Reactome, this protein belongs to the following pathway:
Agmatine biosynthesis  REACT_14800  
 
More information is available from:
Caution 
Was initially reported to have ornithine decarboxylase (PubMed11587527) or arginine decarboxylase (PubMed14738999) activities, but it was later found that the mouse ortholog does not possess either of them.  
3
  • UniProtKB
 

Keywords

Biological process 
Polyamine biosynthesis  definition   [KW-0620]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ADC_(gene)
GenomeRNAi: 113451
PRO: PR:Q96A70