NTAN1 - Protein N-terminal asparagine amidohydrolase - human protein (Function)
 
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NTAN1 »  Protein N-terminal asparagine amidohydrolase   [ EC 3.5.1.- ]
 
Protein also known as:  Protein NH2-terminal asparagine amidohydrolase (PNAA).
Gene name:  NTAN1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Side-chain deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N-terminal asparagine to aspartate by PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme does not act on substrates with internal or C-terminal asparagines and does not act on glutamine residues in any position, nor on acetylated N-terminal peptidyl Asn.  
1
  • CuratedUniProtKB
GO molecular function 
Protein-N-terminal asparagine amidohydrolase activitydefinition[GO:0008418] silver  
  • IEAOrtholog Compara
GO biological process 
Adult locomotory behaviordefinition[GO:0008344] silver  
  • IEAOrtholog Compara
Memorydefinition[GO:0007613] silver  
  • IEAOrtholog Compara
Metabolic processdefinition[GO:0008152]  
  • IEAUniProtKB KW
  • IEAInterPro 2 GO
  • IEAOrtholog Compara
Enzymatic activity 
It is regulated in the following manner
Inhibited by micromolar concentrations of copper and zinc ions.  
1
  • CuratedUniProtKB
 

Biophysicochemical properties

Dependence
pH Optimum pH is 6.0-7.5.

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 123803
PRO: PR:Q96AB6