RPE - Ribulose-phosphate 3-epimerase - human protein (Function)
 
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RPE »  Ribulose-phosphate 3-epimerase   [ EC 5.1.3.1 ]
 
Protein also known as:  Ribulose-5-phosphate-3-epimerase.
Gene name:  RPE
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.  
1
  • CuratedUniProtKB
GO molecular function 
Identical protein bindingdefinition[GO:0042802]  
2
  • IPIIntAct
Metal ion bindingdefinition[GO:0046872]  
1
  • IDAUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IPIUniProtKB
Ribulose-phosphate 3-epimerase activitydefinition[GO:0004750]  
1
  • IDAUniProtKB
GO biological process 
Carbohydrate metabolic processdefinition[GO:0005975]  
1
  • IDAUniProtKB
Pentose-phosphate shuntdefinition[GO:0006098]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5.1.3.1: D-ribulose 5-phosphate D-xylulose 5-phosphate.  
1
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 divalent metal cation per subunit. Active with Fe(2+), and probably also with Mn(2+), Zn(2+) and Co(2+).  
1
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+6120  
Pentose and glucuronate interconversions  hsa00040+6120  
Pentose phosphate pathway  hsa00030+6120  
According to Reactome, this protein belongs to the following pathway:
Pentose phosphate pathway (hexose monophosphate shunt)  REACT_1859  
 

Keywords

Biological process 
Carbohydrate metabolism  definition   [KW-0119]
Molecular function 
Isomerase  definition   [KW-0413]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: RPE_(gene)
GenomeRNAi: 6120
PRO: PR:Q96AT9