CREB3L1 - Cyclic AMP-responsive element-binding protein 3-like protein 1 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
CREB3L1 »  Cyclic AMP-responsive element-binding protein 3-like protein 1  (cAMP-responsive element-binding protein 3-like protein 1)
 
Protein also known as:  Old astrocyte specifically-induced substance (OASIS). Cleaved into:  Processed cyclic AMP-responsive element-binding protein 3-like protein 1.
Gene name:  CREB3L1
Family name: bZIP » ATF
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 40 2
GENE REF ISO

Function

 show evidences
Overview 
Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in bone formation through the transcription of COL1A1, and possibly COL1A2, and the secretion of bone matrix proteins. Directly binds to the UPR element (UPRE)-like sequence in an osteoblast-specific COL1A1 promoter region and induces its transcription. Does not regulate COL1A1 in other tissues, such as skin (By similarity). Required to protect astrocytes from ER stress-induced cell death. In astrocytes, binds to the cAMP response element (CRE) of the BiP/HSPA5 promoter and participate in its transcriptional activation (By similarity). May play a role in limiting virus spread by inhibiting proliferation of virus-infected cells. Upon infection with diverse DNA and RNA viruses, inhibits cell-cycle progression by binding to promoters and activating transcription of genes encoding cell-cycle inhibitors, such as p21/CDKN1A (PubMed21767813). Binds the DNA consensus sequence 5'-GTGXGCXGC-3' (PubMed21767813).  
4
  • UniProtKB
GO molecular function 
cAMP response element bindingdefinition[GO:0035497]  
1
  • Ortholog Curator
Chromatin bindingdefinition[GO:0003682]  
1
  • Ortholog Curator
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
1
  • InterPro 2 GO
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • Ortholog Curator
Transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingdefinition[GO:0001077]  
1
  • Ortholog Curator
GO biological process 
Endoplasmic reticulum unfolded protein responsedefinition[GO:0030968]  
1
  • Ortholog Curator
Extracellular matrix constituent secretiondefinition[GO:0070278]  
1
  • Ortholog Curator
Multicellular organismal developmentdefinition[GO:0007275]  
1
  • UniProtKB KW
Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwaydefinition[GO:1902236]  
1
  • Ortholog Curator
Osteoblast differentiationdefinition[GO:0001649]  
1
  • Ortholog Curator
Positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stressdefinition[GO:1990440]  
1
  • Ortholog Curator
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • Ortholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cholinergic synapse  hsa04725+90993  
Dopaminergic synapse  hsa04728+90993  
Huntington's disease  hsa05016+90993  
Melanogenesis  hsa04916+90993  
Prostate cancer  hsa05215+90993  
Vasopressin-regulated water reabsorption  hsa04962+90993  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Unfolded protein response  definition   [KW-0834]
Molecular function 
Activator  definition   [KW-0010]
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 90993
PRO: PR:Q96BA8