CREB3L1 - Cyclic AMP-responsive element-binding protein 3-like protein 1 - human protein (Function)
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CREB3L1 »  Cyclic AMP-responsive element-binding protein 3-like protein 1  (cAMP-responsive element-binding protein 3-like protein 1)
Protein also known as:  Old astrocyte specifically-induced substance (OASIS). Cleaved into:  Processed cyclic AMP-responsive element-binding protein 3-like protein 1.
Gene name:  CREB3L1
Family name: bZIP » ATF
Entry whose protein(s) existence is based on evidence at protein level
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Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system (By similartity). May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682] silver  
  • IEAOrtholog Compara
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077] silver  
  • IEAOrtholog Compara
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAInterPro 2 GO
GO biological process 
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
  • IEAOrtholog Compara
Regulation of bone mineralizationdefinition[GO:0030500] silver  
  • IEAOrtholog Compara
Response to unfolded proteindefinition[GO:0006986]  
  • IEAUniProtKB KW
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
According to KEGG, this protein belongs to the following pathways:
Cholinergic synapse  hsa04725+90993  
Dopaminergic synapse  hsa04728+90993  
Huntington's disease  hsa05016+90993  
Melanogenesis  hsa04916+90993  
Prostate cancer  hsa05215+90993  
Vasopressin-regulated water reabsorption  hsa04962+90993  


Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Unfolded protein response  definition   [KW-0834]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GenomeRNAi: 90993