SLC22A18 - Solute carrier family 22 member 18 - human protein (Function)
 
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Protein
Gene
References

 
SLC22A18 »  Solute carrier family 22 member 18
 
Protein also known as:  Tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein.
Gene name:  SLC22A18
Entry whose protein(s) existence is based on evidence at protein level
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1 27 1
GENE REF ISO

Function

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Overview 
May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the major facilitator superfamily (mfs)  2.A.1.2.53  
GO molecular function 
Drug transmembrane transporter activitydefinition[GO:0015238]  
1
  • IDAUniProtKB
Symporter activitydefinition[GO:0015293]  
  • IEAUniProtKB KW
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • IPIUniProtKB
GO biological process 
Drug transmembrane transportdefinition[GO:0006855]  
1
  • IDAGOC
Drug transportdefinition[GO:0015893]  
1
  • IDAUniProtKB
Excretiondefinition[GO:0007588]  
1
  • NASUniProtKB
Organic cation transportdefinition[GO:0015695]  
1
  • NASUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Transmembrane transport of small molecules  REACT_15518  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Symport  definition   [KW-0769]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SLC22A18
GenomeRNAi: 5002
PRO: PR:Q96BI1