APH1A - Gamma-secretase subunit APH-1A - human protein (Function)
 
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APH1A »  Gamma-secretase subunit APH-1A  (APH-1a)
 
Protein also known as:  Presenilin-stabilization factor.
Gene name:  APH1A
Family name: APH-1
Entry whose protein(s) existence is based on evidence at protein level
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1 44 3
GENE REF ISO

Function

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Overview 
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.  
3
  • CuratedUniProtKB
GO molecular function 
Endopeptidase activitydefinition[GO:0004175] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
GO biological process 
Amyloid precursor protein catabolic processdefinition[GO:0042987]  
2
  • TASHGNC
  • IMPUniProtKB
Membrane protein ectodomain proteolysisdefinition[GO:0006509]  
1
  • IDAHGNC
Membrane protein intracellular domain proteolysisdefinition[GO:0031293]  
1
  • IMPUniProtKB
Metanephros developmentdefinition[GO:0001656] silver  
  • IEAOrtholog Compara
Notch receptor processingdefinition[GO:0007220]  
2
  • TASHGNC
  • IMPUniProtKB
Positive regulation of catalytic activitydefinition[GO:0043085]  
1
  • IDAHGNC
Protein processingdefinition[GO:0016485]  
1
  • IDAHGNC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+51107  
Notch signaling pathway  hsa04330+51107  
According to Reactome, this protein belongs to the following pathways:
A third proteolytic cleavage releases NICD  REACT_691  
Disease  REACT_116125  
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Notch signaling pathway  definition   [KW-0914]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 51107
PRO: PR:Q96BI3