SGK3 - Serine/threonine-protein kinase Sgk3 - human protein (Function)
 
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SGK3 »  Serine/threonine-protein kinase Sgk3   [ EC 2.7.11.1 ]
 
Protein also known as:  Serum/glucocorticoid-regulated kinase-like.
Gene name:  SGK3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes.  
22
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Calcium channel regulator activitydefinition[GO:0005246]  
1
  • UniProtKB
Chloride channel regulator activitydefinition[GO:0017081]  
1
  • UniProtKB
Phosphatidylinositol bindingdefinition[GO:0035091] silver  
1
  • InterPro 2 GO
Potassium channel regulator activitydefinition[GO:0015459]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Protein kinase activitydefinition[GO:0004672]  
2
  • PINC
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • UniProtKB KW
Sodium channel regulator activitydefinition[GO:0017080]  
1
  • UniProtKB
GO biological process 
Protein phosphorylationdefinition[GO:0006468] silver  
1
  • InterPro 2 GO
Regulation of cell growthdefinition[GO:0001558]  
1
  • UniProtKB
Regulation of cell migrationdefinition[GO:0030334]  
1
  • UniProtKB
Regulation of cell proliferationdefinition[GO:0042127]  
1
  • UniProtKB
Regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0051090]  
1
  • UniProtKB
Response to stressdefinition[GO:0006950]  
1
  • PINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
1
  • UniProtKB
It is regulated in the following manner
Two specific sites, one in the kinase domain (Thr-320) and the other in the C-terminal regulatory region (Ser-486), need to be phosphorylated for its full activation.  
1
  • UniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Stimuli-sensing channels  REACT_160189  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: SGK3
PRO: PR:Q96BR1
Chemistry
GuidetoPHARMACOLOGY: 1536