PPCDC - Phosphopantothenoylcysteine decarboxylase - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
PPCDC »  Phosphopantothenoylcysteine decarboxylase   [ EC 4.1.1.36 ]  (PPC-DC)
 
Protein also known as:  CoaC.
Gene name:  PPCDC
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 15 2
GENE REF ISO

Function

 show evidences
Overview 
Necessary for the biosynthesis of coenzyme A. Catalyzes the decarboxylation of 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine.  
3
  • UniProtKB
GO molecular function 
Phosphopantothenoylcysteine decarboxylase activitydefinition[GO:0004633]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
GO biological process 
Coenzyme A biosynthetic processdefinition[GO:0015937]  
2
  • UniProtKB
  • UniPathway
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.1.1.36: N-((R)-4'-phosphopantothenoyl)-L-cysteine pantotheine 4'-phosphate + CO(2).  
1
  • UniProtKB
It requires the following cofactor
 FMN : Binds 1 FMN per subunit.  
1
  • UniProtKB
Pathways 
This protein is involved in the following pathway
Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5  
1
  • UniProtKB
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+60490  
Pantothenate and CoA biosynthesis  hsa00770+60490  
According to Reactome, this protein belongs to the following pathway:
Coenzyme A biosynthesis  REACT_11218  
 

Keywords

Biological process 
Coenzyme A biosynthesis  definition   [KW-0173]
Molecular function 
Decarboxylase  definition   [KW-0210]
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q96CD2
Other
GenomeRNAi: 60490
PRO: PR:Q96CD2