TIFA - TRAF-interacting protein with FHA domain-containing protein A - human protein (Function)
 
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Protein
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TIFA »  TRAF-interacting protein with FHA domain-containing protein A
 
Protein also known as:  Putative NF-kappa-B-activating protein 20.
Gene name:  TIFA
Entry whose protein(s) existence is based on evidence at protein level
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1 17 1
GENE REF ISO

Function

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Overview 
Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. Induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism.  
2
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
GO biological process 
I-kappaB kinase/NF-kappaB signalingdefinition[GO:0007249] silver  
  • IEAOrtholog Compara
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 92610
PRO: PR:Q96CG3