ARHGEF26 - Rho guanine nucleotide exchange factor 26 - human protein (Function)
 
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Protein
Gene
References

 
ARHGEF26 »  Rho guanine nucleotide exchange factor 26
 
Protein also known as:  SH3 domain-containing guanine exchange factor.
Gene name:  ARHGEF26
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry.  
3
  • CuratedUniProtKB
GO molecular function 
Rho guanyl-nucleotide exchange factor activitydefinition[GO:0005089] silver  
  • IEAInterPro 2 GO
Pathways 
According to KEGG, this protein belongs to the following pathway:
Bacterial invasion of epithelial cells  hsa05100+26084  
 

Keywords

Molecular function 
Guanine-nucleotide releasing factor  definition   [KW-0344]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 26084
PRO: PR:Q96DR7