ATG4C - Cysteine protease ATG4C - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
ATG4C »  Cysteine protease ATG4C   [ EC 3.4.22.- ]
 
Protein also known as:  Autophagy-related cysteine endopeptidase 3.
Gene name:  ATG4C
Family name: Peptidase C54
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 19 1
GENE REF ISO

Function

 show evidences
Overview 
Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation (By similarity). Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.  
1
  • CuratedUniProtKB
GO molecular function 
Cysteine-type endopeptidase activitydefinition[GO:0004197]  
1
  • IMPUniProtKB
Peptidase activitydefinition[GO:0008233]  
1
  • IDAUniProtKB
GO biological process 
Autophagic vacuole assemblydefinition[GO:0000045]  
1
  • IGIUniProtKB
Autophagydefinition[GO:0006914]  
1
  • IGIUniProtKB
Protein targeting to membranedefinition[GO:0006612]  
1
  • ISSUniProtKB
Proteolysisdefinition[GO:0006508]  
1
  • IDAUniProtKB
Enzymatic activity 
It is regulated in the following manner
Inhibited by N-ethylmaleimide.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Regulation of autophagy  hsa04140+84938  
 

Biophysicochemical properties

Kinetic parameters
KM 47.5 uM for MAP1LC3B
KM 12.4 uM for GABARAPL2

Keywords

Biological process 
Autophagy  definition   [KW-0072]
Protein transport  definition   [KW-0653]
Transport  definition   [KW-0813]
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 84938
PRO: PR:Q96DT6