L3HYPDH - Trans-L-3-hydroxyproline dehydratase - human protein (Function)
 
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Protein
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References

 
L3HYPDH »  Trans-L-3-hydroxyproline dehydratase
 
Gene name:  L3HYPDH
Family name: Proline racemase
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalyzes the dehydration of trans-3-hydroxy-L-proline to delta-1-pyrroline-2-carboxylate (Pyr2C). May be required to degrade trans-3-hydroxy-L-proline from the diet and originating from the degradation of proteins such as collagen-IV that contain it.  
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  • CuratedUniProtKB
GO molecular function 
Hydro-lyase activitydefinition[GO:0016836]  
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  • IDAUniProtKB
Not  Proline racemase activitydefinition[GO:0018112]  
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  • IDAUniProtKB
Trans-L-3-hydroxyproline dehydratase activitydefinition[GO:0050346]  
  • IEAEC 2 GO
GO biological process 
Metabolic processdefinition[GO:0008152]  
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  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.2.1.77: Trans-3-hydroxy-L-proline 1-pyrroline 2-carboxylate + H(2)O.  
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  • CuratedUniProtKB
Note 
In contrast to the T.cruzi proline racemase enzyme, lacks the conserved Cys at position 273 which is replaced by a Thr residue, transforming the racemase activity into dehydratase activity (PubMed22528483).  
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  • CuratedUniProtKB
 

Biophysicochemical properties

Kinetic parameters
KM 7.23 mM for trans-3-hydroxy-L-proline
Vmax 39.5 umol/min/mg enzyme
Dependence
pH Optimum pH is 8.0.

Keywords

Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 112849
PRO: PR:Q96EM0