L3HYPDH - Trans-3-hydroxy-L-proline dehydratase - human protein (Function)
 
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L3HYPDH »  Trans-3-hydroxy-L-proline dehydratase   [ EC 4.2.1.77 ]
 
Protein also known as:  Trans-L-3-hydroxyproline dehydratase.
Gene name:  L3HYPDH
Family name: Proline racemase
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalyzes the dehydration of trans-3-hydroxy-L-proline to Delta(1)-pyrroline-2-carboxylate (Pyr2C). May be required to degrade trans-3-hydroxy-L-proline from the diet and originating from the degradation of proteins such as collagen-IV that contain it.  
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  • UniProtKB
GO molecular function 
Hydro-lyase activitydefinition[GO:0016836]  
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  • UniProtKB
Not  Proline racemase activitydefinition[GO:0018112]  
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  • UniProtKB
Trans-L-3-hydroxyproline dehydratase activitydefinition[GO:0050346]  
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  • EC 2 GO
GO biological process 
Metabolic processdefinition[GO:0008152]  
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  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.2.1.77: Trans-3-hydroxy-L-proline 1-pyrroline 2-carboxylate + H(2)O.  
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  • UniProtKB
Note 
In contrast to the T.cruzi proline racemase enzyme, lacks the conserved Cys at position 273 which is replaced by a Thr residue, transforming the racemase activity into dehydratase activity.  
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  • UniProtKB
 

Biophysicochemical properties

Kinetic parameters
KM 7.23 mM for trans-3-hydroxy-L-proline
Vmax 39.5 umol/min/mg enzyme
Dependence
pH Optimum pH is 8.0.

Keywords

Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 112849
PRO: PR:Q96EM0