C1GALT1C1 - C1GALT1-specific chaperone 1 - human protein (Function)
 
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Protein
Gene
References

 
C1GALT1C1 »  C1GALT1-specific chaperone 1
 
Protein also known as:  Core 1 beta3-galactosyltransferase-specific molecular chaperone.
Gene name:  C1GALT1C1
Entry whose protein(s) existence is based on evidence at protein level
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1 34 1
GENE REF ISO

Function

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Overview 
Probable chaperone required for the generation of 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1).  
1
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Enzymatic activity 
According to CAZy, this protein is belongs to the following pathway:
Glycosyltransferase Family 31  GT31  
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+29071  
Mucin type O-Glycan biosynthesis  hsa00512+29071  
According to Reactome, this protein belongs to the following pathway:
Metabolism of proteins  REACT_17015  
Caution 
Was originally (PubMed12361956) assigned to be a glycosyltransferase. However, it was later shown (Ref.2 and PubMed12464682) that it has no transferase activity and rather acts as a chaperone.  
2
  • CuratedUniProtKB
 

Keywords

Molecular function 
Chaperone  definition   [KW-0143]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 29071
PRO: PR:Q96EU7