DTNBP1 - Dysbindin - human protein (Function)
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DTNBP1 »  Dysbindin
Protein also known as:  Biogenesis of lysosome-related organelles complex 1 subunit 8 (BLOC-1 subunit 8).
Gene name:  DTNBP1
Family name: Dysbindin
Entry whose protein(s) existence is based on evidence at protein level
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Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway.  
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
  • IPIIntAct
  • IPIUniProtKB
GO biological process 
Actin cytoskeleton reorganizationdefinition[GO:0031532]  
  • ISSOrtholog Curator
Anterograde axon cargo transportdefinition[GO:0008089]  
  • ISSOrtholog Curator
Anterograde synaptic vesicle transportdefinition[GO:0048490]  
  • ISSOrtholog Curator
Blood coagulationdefinition[GO:0007596] silver  
  • IEAOrtholog Compara
Melanosome organizationdefinition[GO:0032438]  
  • NASUniProtKB
Neuron projection developmentdefinition[GO:0031175]  
  • IDAUniProtKB
Neuron projection morphogenesisdefinition[GO:0048812]  
  • ISSOrtholog Curator
Platelet dense granule organizationdefinition[GO:0060155] silver  
  • IEAOrtholog Compara
Positive regulation of gene expressiondefinition[GO:0010628]  
  • ISSOrtholog Curator
Positive regulation of neurotransmitter secretiondefinition[GO:0001956]  
  • ISSOrtholog Curator
Regulation of dopamine receptor signaling pathwaydefinition[GO:0060159]  
  • ISSOrtholog Curator
Regulation of dopamine secretiondefinition[GO:0014059]  
  • ISSOrtholog Curator
According to Reactome, this protein belongs to the following pathway:
Golgi Associated Vesicle Biogenesis  REACT_19400  


Biological process 
Sensory transduction  definition   [KW-0716]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: Dysbindin
GenomeRNAi: 84062