DNAJA3 - DnaJ homolog subfamily A member 3, mitochondrial - human protein (Function)
 
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DNAJA3 »  DnaJ homolog subfamily A member 3, mitochondrial
 
Protein also known as:  Hepatocellular carcinoma-associated antigen 57.
Gene name:  DNAJA3
Entry whose protein(s) existence is based on evidence at protein level
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1 48 2
GENE REF ISO

Function

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Overview 
Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation.  
  • CuratedUniProtKB
Isoform  Iso 1   Increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity.  
  • CuratedUniProtKB
Isoform  Iso 2   May play a role in neuromuscular junction development as an effector of the MUSK signaling pathway.  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524] silver  
  • IEAInterPro 2 GO
Hsp70 protein bindingdefinition[GO:0030544] silver  
  • IEAOrtholog Compara
Interferon-gamma receptor bindingdefinition[GO:0005133]  
1
  • IDAUniProtKB
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
NF-kappaB bindingdefinition[GO:0051059]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
8
  • IPIIntAct
  • IPIUniProtKB
Protein kinase bindingdefinition[GO:0019901]  
2
  • IPIUniProtKB
Receptor tyrosine kinase bindingdefinition[GO:0030971] silver  
  • IEAOrtholog Compara
Small GTPase regulator activitydefinition[GO:0005083] silver  
  • IEAOrtholog Compara
Isoform  Iso 1   Transcription factor bindingdefinition[GO:0008134]  
2
  • IPIUniProtKB
Unfolded protein bindingdefinition[GO:0051082] silver  
  • IEAOrtholog Compara
GO biological process 
Isoform  Iso 1   Activation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0006919]  
1
  • IDAUniProtKB
Activation-induced cell death of T cellsdefinition[GO:0006924] silver  
  • IEAOrtholog Compara
Cell agingdefinition[GO:0007569] silver  
  • IEAOrtholog Compara
Embryo developmentdefinition[GO:0009790] silver  
  • IEAOrtholog Compara
Mitochondrial DNA replicationdefinition[GO:0006264] silver  
  • IEAOrtholog Compara
Isoform  Iso 2   Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • IDAUniProtKB
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • IDAUniProtKB
Isoform  Iso 2   Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0043154]  
1
  • IDAUniProtKB
Isoform  Iso 1   Negative regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043124]  
1
  • IDAUniProtKB
Negative regulation of interferon-gamma-mediated signaling pathwaydefinition[GO:0060336]  
1
  • IDAUniProtKB
Isoform  Iso 1   Negative regulation of NF-kappaB transcription factor activitydefinition[GO:0032088]  
1
  • IDAUniProtKB
Negative regulation of protein kinase activitydefinition[GO:0006469]  
1
  • IDAUniProtKB
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • IDAUniProtKB
Isoform  Iso 2   Neuromuscular junction developmentdefinition[GO:0007528]  
1
  • IDAUniProtKB
Isoform  Iso 1   Positive regulation of apoptotic processdefinition[GO:0043065]  
1
  • IDAUniProtKB
Isoform  Iso 2   Positive regulation of protein ubiquitinationdefinition[GO:0031398]  
1
  • IDAUniProtKB
Positive regulation of T cell proliferationdefinition[GO:0042102] silver  
  • IEAOrtholog Compara
Protein foldingdefinition[GO:0006457]  
1
  • IDAUniProtKB
  • IEAInterPro 2 GO
Isoform  Iso 1   Protein stabilizationdefinition[GO:0050821]  
1
  • IDAUniProtKB
Response to heatdefinition[GO:0009408] silver  
  • IEAInterPro 2 GO
Response to interferon-gammadefinition[GO:0034341]  
1
  • IDAUniProtKB
Skeletal muscle acetylcholine-gated channel clusteringdefinition[GO:0071340]  
  • ISSOrtholog Curator
Small GTPase mediated signal transductiondefinition[GO:0007264] silver  
  • IEAOrtholog Compara
T cell differentiation in thymusdefinition[GO:0033077] silver  
  • IEAOrtholog Compara
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Molecular function 
Chaperone  definition   [KW-0143]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: DNAJA3
GenomeRNAi: 9093
PRO: PR:Q96EY1