MVB12A - Multivesicular body subunit 12A - human protein (Function)
 
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Protein
Gene
References

 
MVB12A »  Multivesicular body subunit 12A
 
Protein also known as:  CIN85/CD2AP family-binding protein.
Gene name:  MVB12A
Family name: MVB12
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor.  
1
  • CuratedUniProtKB
GO molecular function 
Lipid bindingdefinition[GO:0008289]  
1
  • IMPUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
SH3 domain bindingdefinition[GO:0017124]  
  • IEAUniProtKB KW
Ubiquitin bindingdefinition[GO:0043130]  
1
  • IMPUniProtKB
GO biological process 
Protein transportdefinition[GO:0015031]  
  • IEAUniProtKB KW
Regulation of epidermal growth factor receptor signaling pathwaydefinition[GO:0042058]  
1
  • IMPUniProtKB
Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathwaydefinition[GO:0043162]  
1
  • ICUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Endocytosis  hsa04144+93343  
 

Keywords

Biological process 
Protein transport  definition   [KW-0653]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 93343
PRO: PR:Q96EY5