P2RY11 - P2Y purinoceptor 11 - human protein (Function)
 
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Protein
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P2RY11 »  P2Y purinoceptor 11  (P2Y11)
 
Gene name:  P2RY11
Entry whose protein(s) existence is based on evidence at protein level
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1 28 1
GENE REF ISO

Function

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Overview 
Receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems. Not activated by UTP or UDP.  
  • CuratedUniProtKB
GO molecular function 
ATP-activated nucleotide receptor activitydefinition[GO:0045031]  
1
  • IDABHF-UCL
G-protein coupled purinergic nucleotide receptor activitydefinition[GO:0045028] silver  
  • IEAInterPro 2 GO
Neurotransmitter receptor activitydefinition[GO:0030594]  
1
  • IDABHF-UCL
Receptor activitydefinition[GO:0004872]  
1
  • TASPINC
GO biological process 
Activation of adenylate cyclase activitydefinition[GO:0007190]  
1
  • TASPINC
Adenosine receptor signaling pathwaydefinition[GO:0001973]  
1
  • IDAGOC
Calcium-mediated signalingdefinition[GO:0019722]  
1
  • IDABHF-UCL
Cellular response to ATPdefinition[GO:0071318]  
1
  • IDABHF-UCL
Defense responsedefinition[GO:0006952]  
1
  • TASPINC
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • IDABHF-UCL
Neuronal signal transductiondefinition[GO:0023041]  
1
  • IDABHF-UCL
Phospholipase C-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007200]  
1
  • TASPINC
Purinergic receptor signaling pathwaydefinition[GO:0035587]  
1
  • IDAGOC
Synaptic transmissiondefinition[GO:0007268]  
1
  • IDAGOC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+5032  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
Note 
A chimeric transcript, characterized by the first third of PPAN exon 12 joined to P2RY11 exon 2, has been detected. It is possibly produced by trans-splicing. The chimeric transcript is widely expressed and can be induced by retinoic acid during the granulocytic differentiation of the HL-60 cell line. The resulting chimeric protein shows a much lower activity than the non-chimeric P2RY11 gene product, but qualitatively indistinguishable (PubMed11278528).  
1
  • CuratedUniProtKB
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: P2RY11
GenomeRNAi: 5032
PRO: PR:Q96G91
Chemistry
GuidetoPHARMACOLOGY: 327