AURKB - Aurora kinase B - human protein (Function)
 
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AURKB »  Aurora kinase B   [ EC 2.7.11.1 ]
 
Protein also known as:  Aurora- and IPL1-like midbody-associated protein 1 (AIM-1).
Gene name:  AURKB
Entry whose protein(s) existence is based on evidence at protein level
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1 240 5
GENE REF ISO

Function

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Overview 
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPT1, VIM/vimentin, GSG2/Haspin, and histone H3. A positive feedback loop involving GSG2 and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively). A positive feedback between GSG2 and AURKB contributes to CPC localization. AURKB is also required for kinetochore localization of BUB1 and SGOL1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activity. Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes.  
17
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Histone serine kinase activitydefinition[GO:0035174]  
  • ISSOrtholog Curator
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
14
  • IPIIntAct
  • IPIUniProtKB
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • IDAFlyBase
Protein serine/threonine/tyrosine kinase activitydefinition[GO:0004712]  
1
  • TASUniProtKB
GO biological process 
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Attachment of spindle microtubules to kinetochoredefinition[GO:0008608]  
1
  • TASUniProtKB
Cell proliferationdefinition[GO:0008283] silver  
  • IEAOrtholog Compara
Cellular response to UVdefinition[GO:0034644]  
1
  • IDAUniProtKB
Cleavage furrow formationdefinition[GO:0036089]  
1
  • IDAUniProtKB
Histone H3-S28 phosphorylationdefinition[GO:0043988]  
  • ISSOrtholog Curator
Histone modificationdefinition[GO:0016570]  
1
  • TASUniProtKB
Negative regulation of B cell apoptotic processdefinition[GO:0002903]  
1
  • IDAUniProtKB
Negative regulation of protein bindingdefinition[GO:0032091]  
1
  • IDAUniProtKB
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • IDAUniProtKB
Positive regulation of cytokinesisdefinition[GO:0032467]  
2
  • TASUniProtKB
Protein autophosphorylationdefinition[GO:0046777]  
1
  • TASUniProtKB
Protein localization to kinetochoredefinition[GO:0034501]  
1
  • IMPUniProtKB
Protein phosphorylationdefinition[GO:0006468]  
2
  • IDAFlyBase
  • IDAUniProtKB
Regulation of chromosome segregationdefinition[GO:0051983]  
1
  • TASUniProtKB
Spindle checkpointdefinition[GO:0031577] silver  
  • IEAInterPro 2 GO
Spindle midzone assembly involved in mitosisdefinition[GO:0051256]  
2
  • TASUniProtKB
Spindle stabilizationdefinition[GO:0043146]  
1
  • IMPUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium.  
  • CuratedUniProtKB
It is regulated in the following manner
Activity is greatly increased when AURKB is within the CPC complex. In particular, AURKB-phosphorylated INCENP acts as an activator of AURKB. Positive feedback between GSG2 and AURKB contributes to CPC localization.  
3
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
Cell Cycle  REACT_115566  
Mitotic M-M/G1 phases  REACT_21300  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Cell division  definition   [KW-0132]
Mitosis  definition   [KW-0498]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Aurora_B_kinase
GenomeRNAi: 9212
PRO: PR:Q96GD4
Chemistry
GuidetoPHARMACOLOGY: 1937