AURKB - Aurora kinase B - human protein (Function)
 
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Protein
Gene
References

 
AURKB »  Aurora kinase B   [ EC 2.7.11.1 ]
 
Protein also known as:  Aurora- and IPL1-like midbody-associated protein 1 (AIM-1).
Gene name:  AURKB
Entry whose protein(s) existence is based on evidence at protein level
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1 295 5
GENE REF ISO

Function

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Overview 
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed22422861, PubMed24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPT1, VIM/vimentin, GSG2/Haspin, and histone H3. A positive feedback loop involving GSG2 and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively). A positive feedback between GSG2 and AURKB contributes to CPC localization. AURKB is also required for kinetochore localization of BUB1 and SGOL1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activity. Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes.  
20
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Histone serine kinase activitydefinition[GO:0035174]  
2
  • RefGenome
  • Ortholog Curator
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
17
  • IntAct
  • UniProtKB
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • FlyBase
Protein serine/threonine/tyrosine kinase activitydefinition[GO:0004712]  
1
  • UniProtKB
GO biological process 
Abscissiondefinition[GO:0009838]  
1
  • Ortholog Curator
Agingdefinition[GO:0007568] silver  
1
  • Ortholog Compara
Attachment of spindle microtubules to kinetochoredefinition[GO:0008608]  
1
  • UniProtKB
Cell proliferationdefinition[GO:0008283] silver  
1
  • Ortholog Compara
Cellular response to UVdefinition[GO:0034644]  
1
  • UniProtKB
Cleavage furrow formationdefinition[GO:0036089]  
1
  • UniProtKB
Histone H3-S28 phosphorylationdefinition[GO:0043988]  
1
  • Ortholog Curator
Histone modificationdefinition[GO:0016570]  
1
  • UniProtKB
Mitotic spindle midzone assemblydefinition[GO:0051256]  
2
  • UniProtKB
Negative regulation of B cell apoptotic processdefinition[GO:0002903]  
1
  • UniProtKB
Negative regulation of cytokinesisdefinition[GO:0032466]  
1
  • Ortholog Curator
Negative regulation of protein bindingdefinition[GO:0032091]  
1
  • UniProtKB
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • UniProtKB
Positive regulation of cytokinesisdefinition[GO:0032467]  
2
  • UniProtKB
Protein autophosphorylationdefinition[GO:0046777]  
1
  • UniProtKB
Protein localization to kinetochoredefinition[GO:0034501]  
1
  • UniProtKB
Protein phosphorylationdefinition[GO:0006468]  
2
  • FlyBase
  • UniProtKB
Regulation of chromosome segregationdefinition[GO:0051983]  
1
  • UniProtKB
Spindle checkpointdefinition[GO:0031577] silver  
1
  • InterPro 2 GO
Spindle stabilizationdefinition[GO:0043146]  
1
  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
1
  • UniProtKB
It requires the following cofactor
 Mg(2+)  
1
  • UniProtKB
It is regulated in the following manner
Activity is greatly increased when AURKB is within the CPC complex. In particular, AURKB-phosphorylated INCENP acts as an activator of AURKB. Positive feedback between GSG2 and AURKB contributes to CPC localization.  
4
  • UniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1  REACT_6761  
Mitotic Prometaphase  REACT_682  
Resolution of Sister Chromatid Cohesion  REACT_150425  
Separation of Sister Chromatids  REACT_150471  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Cell division  definition   [KW-0132]
Mitosis  definition   [KW-0498]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Aurora_B_kinase
GenomeRNAi: 9212
PRO: PR:Q96GD4
Chemistry
GuidetoPHARMACOLOGY: 1937