SMARCD1 - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 - human protein (Function)
 
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SMARCD1 »  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
 
Protein also known as:  60 kDa BRG-1/Brm-associated factor subunit A.
Gene name:  SMARCD1
Family name: SMARCD
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 29 2
GENE REF ISO

Function

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Overview 
Involved in chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Has a strong influence on vitamin D-mediated transcriptional activity from an enhancer vitamin D receptor element (VDRE). May be a link between mammalian SWI-SNF-like chromatin remodeling complexes and the vitamin D receptor (VDR) heterodimer. Mediates critical interactions between nuclear receptors and the BRG1/SMARCA4 chromatin-remodeling complex for transactivation.  
4
  • UniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
6
  • IntAct
Protein complex scaffolddefinition[GO:0032947]  
1
  • UniProtKB
Transcription coactivator activitydefinition[GO:0003713]  
1
  • BHF-UCL
GO biological process 
Chromatin remodelingdefinition[GO:0006338]  
2
  • UniProtKB
  • BHF-UCL
Chromatin-mediated maintenance of transcriptiondefinition[GO:0048096]  
1
  • UniProtKB
Nervous system developmentdefinition[GO:0007399]  
1
  • UniProtKB KW
Nucleosome disassemblydefinition[GO:0006337]  
1
  • BHF-UCL
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • BHF-UCL
Pathways 
According to Reactome, this protein belongs to the following pathway:
RMTs methylate histone arginines  REACT_264545  
 

Keywords

Biological process 
Neurogenesis  definition   [KW-0524]
Molecular function 
Chromatin regulator  definition   [KW-0156]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SMARCD1
GenomeRNAi: 6602
PRO: PR:Q96GM5