ACSBG1 - Long-chain-fatty-acid--CoA ligase ACSBG1 - human protein (Function)
 
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ACSBG1 »  Long-chain-fatty-acid--CoA ligase ACSBG1   [ EC 6.2.1.3 ]
 
Protein also known as:  Acyl-CoA synthetase bubblegum family member 1.
Gene name:  ACSBG1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 24 1
GENE REF ISO

Function

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Overview 
Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids.  
2
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Long-chain fatty acid-CoA ligase activitydefinition[GO:0004467]  
1
  • IDAHGNC
Very long-chain fatty acid-CoA ligase activitydefinition[GO:0031957]  
1
  • IDAHGNC
GO biological process 
Long-chain fatty acid metabolic processdefinition[GO:0001676]  
1
  • IDAHGNC
Myelinationdefinition[GO:0042552]  
1
  • NASHGNC
Ovarian follicle atresiadefinition[GO:0001552] silver  
  • IEAOrtholog Compara
Response to glucocorticoiddefinition[GO:0051384] silver  
  • IEAOrtholog Compara
Very long-chain fatty acid metabolic processdefinition[GO:0000038]  
1
  • IDAHGNC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 6.2.1.3: ATP + a long-chain fatty acid + CoA AMP + diphosphate + an acyl-CoA.  
1
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adipocytokine signaling pathway  hsa04920+23205  
Fatty acid metabolism  hsa00071+23205  
Metabolic pathways  hsa01100+23205  
PPAR signaling pathway  hsa03320+23205  
 
More information is available from:
 

Keywords

Biological process 
Fatty acid metabolism  definition   [KW-0276]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ACSBG1
GenomeRNAi: 23205
PRO: PR:Q96GR2