APIP - Methylthioribulose-1-phosphate dehydratase - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
APIP »  Methylthioribulose-1-phosphate dehydratase   [ EC 4.2.1.109 ]  (MTRu-1-P dehydratase)
 
Protein also known as:  APAF1-interacting protein.
Gene name:  APIP
Family name: Aldolase class II » MtnB
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 22 2
GENE REF ISO

Function

 show evidences
Overview 
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.  
3
  • CuratedUniProtKB
GO molecular function 
Identical protein bindingdefinition[GO:0042802]  
2
  • IPIIntAct
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Zinc ion bindingdefinition[GO:0008270]  
  • IEAUniProtKB Annot
GO biological process 
Apoptotic processdefinition[GO:0006915]  
  • IEAUniProtKB KW
L-methionine biosynthetic process from methylthioadenosinedefinition[GO:0019509]  
2
  • IMPUniProtKB
  • IEAUniPathway
L-methionine biosynthetic process from S-adenosylmethioninedefinition[GO:0019284]  
  • IEAUniProtKB Annot
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • IMPUniProtKB
Regulation of ERK1 and ERK2 cascadedefinition[GO:0070372]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.2.1.109: S-methyl-5-thio-D-ribulose 1-phosphate 5-(methylthio)-2,3-dioxopentyl phosphate + H(2)O.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 zinc ion per subunit (By similarity).  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Cysteine and methionine metabolism  hsa00270+51074  
Metabolic pathways  hsa01100+51074  
According to Reactome, this protein belongs to the following pathway:
Methionine salvage pathway  REACT_75881  
 

Keywords

Biological process 
Amino-acid biosynthesis  definition   [KW-0028]
Apoptosis  definition   [KW-0053]
Methionine biosynthesis  definition   [KW-0486]
Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: APIP
GenomeRNAi: 51074
PRO: PR:Q96GX9