COQ2 - 4-hydroxybenzoate polyprenyltransferase, mitochondrial - human protein (Function)
 
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Protein
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COQ2 »  4-hydroxybenzoate polyprenyltransferase, mitochondrial   [ EC 2.5.1.39 ]
 
Protein also known as:  Para-hydroxybenzoate--polyprenyltransferase (PHB:polyprenyltransferase).
Gene name:  COQ2
Family name: UbiA prenyltransferase
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB.  
1
  • CuratedUniProtKB
GO molecular function 
4-hydroxybenzoate decaprenyltransferase activitydefinition[GO:0002083]  
  • IEAEC 2 GO
4-hydroxybenzoate nonaprenyltransferase activitydefinition[GO:0047293]  
  • IEAEC 2 GO
GO biological process 
Cell deathdefinition[GO:0008219]  
  • IEAUniProtKB KW
Glycerol metabolic processdefinition[GO:0006071]  
1
  • IGIUniProtKB
Isoprenoid biosynthetic processdefinition[GO:0008299]  
  • IEAUniProtKB KW
Ubiquinone biosynthetic processdefinition[GO:0006744]  
1
  • IDAUniProtKB
  • IEAUniPathway
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.5.1.39: A polyprenyl diphosphate + 4-hydroxybenzoate diphosphate + a 4-hydroxy-3-polyprenylbenzoate.  
1
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+27235  
Ubiquinone and other terpenoid-quinone biosynthesis  hsa00130+27235  
According to Reactome, this protein belongs to the following pathways:
Metabolism  REACT_111217  
Metabolism of proteins  REACT_17015  
 
More information is available from:
 

Keywords

Biological process 
Isoprene biosynthesis  definition   [KW-0414]
Ubiquinone biosynthesis  definition   [KW-0831]
Molecular function 
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: COQ2
GenomeRNAi: 27235
PRO: PR:Q96H96